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OpenTrials
Completed

NCT Number: NCT04705870

Comparison of the Performance of an Optimized 3D EPI SWI Sequence and a Non-EPI QSM SWI Sequence in Detecting the Central Vein Sign in Patients With Multiple Sclerosis

Patients who have agreed to participate in the study will complete the MRI protocol as part of routine care, to which four additional 20-minute sequences will be added.

MRI of routine care in the context of MS includes at least the following sequences:

* 3D T1 TFE (2 minutes) * T2 TSE (2 minutes) * 3D FLAIR (3 minutes) * SWI EPI 0.6 iso (7 minutes)

The sequences added by the search are:

* SWI non EPI QSM 6 echo (10 minutes) * SWI EPI in resolution equivalent to non-EPI SWI (3 minutes) * SWI EPI to TR equivalent to SWI non EPI (6 minutes)

These sequences will be acquired before or after the injection of gadolinium (if present in the examination of routine care). For examinations carried out with injection, the order of carrying out the 4 post-injection SWI sequences will be random.

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Key information

Conditions

Multiple Sclerosis Autoimmune Diseases Autoimmune Diseases of the Nervous System Demyelinating Autoimmune Diseases, CNS Demyelinating Diseases Immune System Diseases Nervous System Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Hhopital fondation adolphe de rothschild

Paris, 75019, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients over 18
  • With MS defined according to the McDonald's revised clinical or radiological spatial and temporal dissemination criteria, with onset of symptoms <5 years
  • To benefit as part of care from an MRI with or without injection of gadolinium
  • Express consent to participate in the study
  • Affiliate or beneficiary of a social security scheme

Exclusion criteria

  • Patient benefiting from a legal protection measure
  • Pregnant or breastfeeding woman

Treatment and study plan

cerebral MRI

Device

MRI of routine care in the context of MS includes at least the following sequences:

  • 3D T1 TFE (2 minutes)
  • T2 TSE (2 minutes)
  • 3D FLAIR (3 minutes)
  • SWI EPI 0.6 iso (7 minutes)

The sequences added by the search are:

  • SWI non EPI QSM 6 echo (10 minutes)
  • SWI EPI in resolution equivalent to non-EPI SWI (3 minutes)
  • SWI EPI to TR equivalent to SWI non EPI (6 minutes)

Primary outcomes

  1. percentage of lesions showing the central vein sign with the SWI EPI sequence that also show the central vein sign with the candidate sequence

    Time frame: 1 day

  2. percentage of lesions which do not present the sign of the central vein with the SWI EPI sequence but which present it with the candidate sequence

    Time frame: 1 day

Sponsors and collaborators

Lead sponsor

Fondation Ophtalmologique Adolphe de Rothschild

Network

Registry information

Acronym: COPEQ-MS

Important dates

Study start
2021
Primary completion
2023
Study completion
2023
First posted
Jan 12, 2021
Registry last updated
Jan 5, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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