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NCT Number: NCT07281807

Comparison of the Pain Levels of Single-Dose Premedication With Piroxicam and Prednisolone on Post-Endodontic Pain in Single-Visit Root Canal Treatment of Premolars

To compare the post operative mean pain scores by administering single-dose preoperative piroxicam and prednisolone in patients of irreversible pulpitis with symptomatic apical periodontitis.

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Key information

Conditions

Irreversible Pulpitis with Apical Periodontitis Symptomatic Apical Periodontitis

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy patient ranging between 18-40 years
  • Having at least one premolar with diagnosis of symptomatic irreversible pulpitis according to history, examination and radiographs.
  • Teeth having mature apex confirmed by periapical radiographs.

Exclusion criteria

  • History of systemic disorders including HIV, Hepatitis
  • Pregnancy (As per Medical record/ Verbally)
  • Patient using medication such as analgesics or anti-inflammatory drugs
  • Patient allergic to lignocaine, piroxicam and prednisolone
  • Tooth not suitable for restoration
  • Periodontal probing depth ≥ 4mm
  • Retreatment cases
  • Patients having calcified canals assessed by radiographic findings

Treatment and study plan

Group B: patients will be given prednisolone 20mg as premedication

Drug

Group B: patients will be given prednisolone 20mg as premedication

piroxicam 20mg

Drug

Group A: patients will be given piroxicam 20mg as premedication

Primary outcomes

  1. pain after single visit root canal treatment

    Time frame: 48 hours

    pain score on visual analogue scale

Study contacts

Contact information is provided by the study sponsor or research team.

rana ahmad, B.D.S., F.C.P.S.

CONTACT

[email protected]

+923335990799

Sponsors and collaborators

Lead sponsor

RANA AHMAD

Other

Registry information

Important dates

Study start
2026
Primary completion
2026
Study completion
2027
First posted
Dec 15, 2025
Registry last updated
Dec 15, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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