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NCT Number: NCT07399223

Comparison of the Metabolomic Effects of Sevoflurane and Desflurane Anesthesia in Laparoscopic Cholecystectomy

Analytical techniques used in metabolomic studies include nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS). The study will involve comparing the metabolomic profiles of patients receiving sevoflurane and desflurane during surgery to identify any differences in metabolic pathways affected by the two anaesthetic techniques. Metabolomic profiles are generated using spectroscopic and spectrometric techniques such as high-field NMR and MS, as well as separation techniques.

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Key information

Conditions

Sevoflurane Desflurane Metabolomic Effect

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

Our study will include 100 patients undergoing laparoscopic cholecystectomy surgery, divided into two groups. Patients aged 18-65 years with an ASA I-II classification, who will undergo laparoscopic cholecystectomy surgery, have no active infection, and have a body mass index (BMI) <35, and who agree to participate in the study, will be intubated after standard anaesthetic induction (propofol, rocuronium, fentanyl) and intubated. The first sample will be taken from the finger immediately after the inhalation anaesthetic (sevoflurane, desflurane) reaches 1 minimal alveolar concentration (MAC) level. The second sample will be taken after the surgical procedure is completed and the inhalation anaesthesia is discontinued. The samples will be taken from the patients' fingertips and absorbed onto Guthrie paper. Statistical analysis will be performed on the data obtained.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients undergoing laparoscopic cholecystectomy surgery who have no active infection, Body mass index (BMI)<35, Aged 18-65, ASA I-II, and who agree to participate in the study

Exclusion criteria

Individuals over 65 years of age ASA 3-4 patients Individuals with a body mass index (BMI) >35 Smokers

Treatment and study plan

Sevoflurane

Procedure

This group will be operated on under sevoflurane.

desflurane

Procedure

This group will be operated on under desflurane.

Primary outcomes

amino acid metabolism

Time frame: 12 weeks
Our primary outcome measure will be the effect of both inhalation anaesthetics on amino acid metabolism.

Time frame: 12 weeks

Study contacts

Contact information is provided by the study sponsor or research team.

Ahmet Atlas

CONTACT

[email protected]

+905322524176

Sponsors and collaborators

Lead sponsor

Harran University

Other

Registry information

Important dates

Study start: 2026
Primary completion: 2026
Study completion: 2026
First posted: Feb 10, 2026
Registry last updated: Feb 23, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.