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OpenTrials
Completed

NCT Number: NCT07054372

Comparison of the Impact of Different Suspension Mediums on ABO Antibody Titres.

Accurate estimation of ABO antibody titres is vital in Transfusion Medicine due to their involvement in hemolytic transfusion reactions, hemolytic disease of the fetus and newborn, and solid-organ transplant rejection. Although the conventional tube technique (CTT) remains the gold standard, its standardization is challenging, partly influenced by the choice of diluents. This study aimed to compare commonly used diluents in ABO antibody titration via CTT and analyze the resulting titre variations.

Completed

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Key information

Conditions

Healthy Blood Donor

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Institute of Liver and Biliary Sciences

New Delhi, National Capital Territory of Delhi, 110070, India

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy Blood Donor.

Exclusion criteria

  • Samples from female donors, those with irregular antibodies and reactive to transfusion-transmissible infections on routine testing, were excluded.

Treatment and study plan

Titres on conventional test tube method with different diluent

Diagnostic Test

Titres on conventional test tube method with different diluent

Primary outcomes

  1. Comparison of the ABO Antibody Titres.

    Time frame: Day 0

Sponsors and collaborators

Lead sponsor

Institute of Liver and Biliary Sciences, India

Other

Registry information

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Jul 8, 2025
Registry last updated
Jul 8, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.