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Completed

NCT Number: NCT06987357

Comparison of the Effects of Sugammadex and Neostigmine on Early Extubation, Intensive Care Unit Admission and Length of Stay, and Hospital Costs in Adult Cranial Surgery

The aim of this study was to retrospectively investigate the effects of sugammadex or neostigmine, which are routinely used after the completion of surgery to antagonize (reverse) neuromuscular blockade in adult patients undergoing cranial surgery under general anesthesia, on early extubation in the operating room, intensive care unit admission and length of stay, length of hospital stay, and hospital costs.

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Key information

Conditions

Craniectomy Extubation Hospital Costs Recovery After Neuromuscular Block Sugammadex

Age range

19 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Kanuni Sultan Suleyman Training and Research Hospital

Istanbul, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients from the American Society of Anesthesiology (ASA) I-II-III group,
  • over the age of 18,
  • who underwent elective surgery,
  • underwent general anesthesia with sevoflurane anesthesia from volatile anesthetics,
  • used rocuronium as a neuromuscular blocking agent

Exclusion criteria

  • Patients aged 18 and under,
  • ASA IV and above,
  • who underwent surgery under emergency conditions,
  • who have incomplete follow-up form records and electronic media data,
  • who were taken to the intensive care unit without neuromuscular blockade antagonism due to long surgery,
  • who were treated with a neuromuscular blocking agent other than rocuronium,
  • who were treated with a volatile anesthetic other than sevoflurane or with total intravenous anesthesia.

Treatment and study plan

Primary outcomes

  1. The amount of cost in the hospital process

    Time frame: through study completion, an average of 3 month

  2. Length of stay in the intensive care unit

    Time frame: through study completion, an average of 3 month

  3. Early extubation rate after two different neuromuscular blocking antagonist drugs

    Time frame: through study completion, an average of 3 month

Sponsors and collaborators

Lead sponsor

Kanuni Sultan Suleyman Training and Research Hospital

Other

Registry information

Important dates

Study start
2021
Primary completion
2021
Study completion
2021
First posted
May 23, 2025
Registry last updated
May 23, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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