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Completed

NCT Number: NCT03920020

Comparison of The Effects of Concentric And Eccentric Isokinetic Exercises in Patients With Knee Osteoarthritis

This study aims to compare the effects of concentric and eccentric isokinetic exercises on proprioception and muscle architecture in 42 patients with knee osteoarthritis enrolled the study.

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Key information

Age range

45 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Institute of Health Sciences

Ankara, Altındağ, 06030, Turkey (Türkiye)

About this study

This study aims to compare the effects of concentric and eccentric isokinetic exercises on proprioception and muscle architecture in patients with knee osteoarthritis. 42 patients will be included in this study. Patients will be divided into three groups; concentric exercise group (n:14), eccentric exercise group (n:14) and control group (n:14). A conventional physiotherapy program and a standard therapeutic exercise program will be applied to all subjects. In addition to these exercise and physiotherapy programme, concentric and eccentric exercise groups will perform the exercises related to their groups. All three groups will participate in this program for a total of 18 sessions 3 times a week for 6 weeks. All groups will be subject to re-evaluation after 6 weeks.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosis of primary knee osteoarthritis according to American College of Radiology
  • Being radiographically K-L grade 2-3
  • Presence of symptoms for at least 3 months
  • Patients who have been planned a conventional physiotherapy programme because of knee osteoarthritis
  • Presence of functional capacity for outpatient physical therapy

Exclusion criteria

  • Patients with seconder knee osteoarthritis
  • History of lower extremity or spine surgery
  • History of intraarticular injection in last 1 month
  • Patients with neurological disease that will affect muscle strength, balance and coordination

Treatment and study plan

the concentric isokinetic exercise group

Other

concentric isokinetic exercises

the eccentric isokinetic exercise group

Other

eccentric isokinetic exercises

The control group

Other

conventional physiotherapy and standard therapeutic exercises predetermined by us

Primary outcomes

  1. Joint position sense

    Time frame: 6 weeks

    Joint position sense will be evaluated with isokinetic dynamometer at predetermined angles.

  2. Ultrasonographic assessment of quadriceps and hamstring muscles

    Time frame: 6 weeks

    Ultrasonographic evaluation is an outcome measure to evaluate muscle structure. In our study ultrasonographic evaluation will be performed to determine the muscle structure (muscle thickness(mm), fascicle length(mm), pennation angle(degree)) of quadriceps and hamstring muscles. Muscle thickness will be defined as the distance between the deeper and upper aponeurosis. The pennation angle will be calculated as the angle of insertion of muscle fascicles into the deep aponeurosis. Fascicle length will be defined as the length of the fascicular path between the superficial and deep aponeurosis.

Secondary outcomes

  1. WOMAC (Western Ontario & McMaster Universities Osteoarthritis Index)

    Time frame: 6 weeks

    WOMAC Osteoarthritis Index (score range 0-100) include 3 subscales and will be used to evaluate knee pain(score range 0-20), stiffness (score range 0-8), and functional limitation (score range -68). Womac is comprised of 24 items ( pain-5 items, stiffness-2 items, physical function-17 items). All items are scored on a scale of 0-4. Lower scores indicate lower disability.

  2. Range of motion

    Time frame: 6 weeks

    Universal goniometer will be used for assessment of range of motion of the knee

  3. Muscle strength assessment

    Time frame: 6 weeks

    isokinetic dynamometer test will be used.

  4. Shortness of muscles assessment

    Time frame: 6 weeks

    universal goniometer will be used for assessment

  5. Pain assessment: VAS (Visual analog scale)

    Time frame: 6 weeks

    VAS is used to measure the psycometric pain severity in some conditions and activities. A VAS is usually a 100 mm long horizontal line. The scale is most commonly anchored by "no pain" (line's left, score-0), "pain as bad as it could be" (line's right, score-100). the score is determined by measuring the distance between the "no pain" anchor and the patient's mark.

  6. Balance assessment

    Time frame: 6 weeks

    Single leg standing test with eyes open and closed will be used. Timing is recorded.

  7. The timed up and go test

    Time frame: 6 weeks

    TUG test is used to measure functional mobility. It gives an idea about patients walking ability, fall risk and balance. The patient is asked to get up, walk 3 meters and sit down again.Timing begins when the patient rise from the chair and stops when the patient sit down.

  8. Sit to stand test

    Time frame: 6 weeks

    Patients stand up from and sit down on a chair as quickly as possible 5 times. Patients folded their arms across their chests. Timing is recorded.

  9. Timed 10 meter walk test

    Time frame: 6 weeks

    This test is used to assess walking speed. Timing is recorded.

  10. Short Form 12 (SF-12) health survey

    Time frame: 6 weeks

    SF-12 is an 12- item questionnare for assessing self-reported health related quality of life. It covers eight domains of health outcomes, including physical functioning, role physical, bodily pain, general health, vitality, social functioning,role-emotional, mental health. Sf-12 physical and mental component summary scales are scored. Lower SF-12 score indicated poorer physical and mental health.

Sponsors and collaborators

Lead sponsor

Hacettepe University

Other

Registry information

Official study title

Comparison of The Effects of Concentric and Eccentric Isokinetic Exercises on Proprioception and Muscle Architecture in Patients With Knee Osteoarthritis

Important dates

Study start
2019
Primary completion
2021
Study completion
2021
First posted
Apr 18, 2019
Registry last updated
Apr 28, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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