Skip to main content
OpenTrials
Active, Not Recruiting

NCT Number: NCT07524933

Comparison of the Effectiveness of Nerve Hydrodissection With Saline Injection of 5% Dextrose in Carpal Tunnel Syndrome.

Comparison of the effectiveness of nerve hydrodissection with saline injection of 5% dextrose in carpal tunnel syndrome.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Notify Me

Key information

Conditions

Conditions Disease Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Antalya Eğitim Araştırma Hastanesi

Antalya, Turkey (Türkiye)

About this study

Evaluation of pain, hand function, electrophysiological and ultrasonographic effects when comparing 5% dextrose saline injection via nerve hydrodissection under ultrasound guidance in mild to moderate carpal tunnel syndrome.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults aged 18-80 years
  • Clinical and electrophysiological diagnosis of mild to moderate carpal tunnel syndrome
  • Symptom duration of at least 3 months
  • Both male and female participants
  • Patients who have not responded adequately to conservative treatment
  • Patients who do not wish to undergo surgical treatment
  • Ability to provide informed consent

Exclusion criteria

  • Severe or very severe carpal tunnel syndrome based on EMG findings
  • Previous injection therapy for carpal tunnel syndrome
  • Prior wrist or carpal tunnel surgery
  • Polyneuropathy or other peripheral neuropathies
  • Cervical radiculopathy or proximal median nerve entrapment
  • Brachial plexopathy or thoracic outlet syndrome
  • Pregnancy
  • Malignancy
  • Local or systemic infection
  • Cognitive impairment affecting cooperation
  • Systemic diseases affecting the median nerve (e.g., uncontrolled diabetes mellitus, thyroid disorders)

Treatment and study plan

Nerve Hydrodissection with 5% Dextrose

Drug

Injection therapy

Other names: Saline Injection (Placebo / Sham), Splint group

Primary outcomes

  1. Change in pain intensity measured by Visual Analog Scale (VAS)

    Time frame: Baseline to 8 month

    The primary outcome is the change in pain intensity assessed by the Visual Analog Scale (VAS, 0-10). The difference between baseline and follow-up scores will be analyzed.

Secondary outcomes

  1. Change in Qucik DASH score

    Time frame: Baseline to 8 month

    Assessed using symptom severity and functional status scales

  2. Change in median nerve cross-sectional area

    Time frame: Baseline to 8 month

    Measured at the carpal tunnel inlet using ultrasonography

  3. hange in nerve conduction study parameters

    Time frame: Baseline to 8 month

    Distal motor latency and sensory conduction velocity of the median nerve

  4. Change in hand grip strength

    Time frame: Baseline to 8 month

    Strength of the arm

Sponsors and collaborators

Lead sponsor

Antalya Training and Research Hospital

Other Gov

Registry information

Official study title

Evaluation of Pain, Hand Function, Electrophysiological and Ultrasonographic Effects When Comparing 5% Dextrose Saline Injection Via Nerve Hydrodissection Under Ultrasound Guidance in Mild to Moderate Carpal Tunnel Syndrome.

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Apr 13, 2026
Registry last updated
Apr 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.