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NCT Number: NCT07242339

Comparison of the Analgesic Efficacy of Adductor Canal Block Versus Adductor Canal Plus Biceps Femoris Short Head Block in Patients Undergoing Knee Arthroscopy

This prospective, randomized, controlled, and multicenter clinical study aims to compare the postoperative analgesic efficacy of two regional anesthesia techniques commonly used in knee arthroscopy: adductor canal block (ACB) and combined adductor canal block plus biceps femoris short head (ACB+BiFeS) block. The study will evaluate postoperative pain control, opioid consumption, adverse effects, hospital stay, and patient satisfaction. Findings will help determine the most effective and safe method for postoperative analgesia in knee arthroscopy patients.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Health Science University İstanbul Kanuni Sultan Süleyman Education and Training Hospital

Istanbul, küçükçekmece, 34303, Turkey (Türkiye)

About this study

Knee arthroscopy is one of the most common orthopedic procedures and is frequently associated with significant postoperative pain. Effective multimodal analgesia is therefore essential to reduce opioid consumption, improve early mobilization, and enhance overall patient recovery. Among the regional anesthesia techniques, the adductor canal block (ACB) is well established as an effective motor-sparing block that provides analgesia to the medial and anterior aspects of the knee. However, patients often continue to experience posterolateral knee pain, which is not consistently relieved by ACB alone.

Recent anatomical and cadaveric studies have described the biceps femoris short head (BiFeS) block as a promising technique for targeting the posterolateral knee compartment. The BiFeS block involves deposition of local anesthetic between the short head of the biceps femoris muscle and the lateral femoral cortex at the supracondylar level. Preliminary findings suggest that this block may provide effective analgesia for the posterolateral knee without causing significant motor impairment.

This prospective, randomized, controlled, multicenter clinical trial is designed to evaluate whether the addition of the BiFeS block to standard ACB improves postoperative analgesia compared with ACB alone in patients undergoing knee arthroscopy under spinal anesthesia. The study will investigate pain scores at rest and during movement, total opioid consumption, side effects, rescue analgesic requirements, and quality of recovery. The dermatomal distribution of the blocks will be optionally assessed using cold testing.

By directly comparing ACB and combined ACB+BiFeS block under standardized perioperative conditions, this study seeks to generate high-quality evidence on the clinical utility of BiFeS as an adjunct technique. The results are expected to guide anesthesiologists in selecting optimal regional analgesia strategies for knee arthroscopy, with the potential to improve patient satisfaction, reduce opioid-related complications, and shorten hospitalization.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≥ 18 years
  • ASA physical status I-III
  • Scheduled for elective knee arthroscopy under spinal anesthesia
  • Ability to provide written informed consent

Exclusion criteria

  • Coagulopathy or bleeding diathesis
  • Current use of anticoagulant therapy
  • Known allergy or contraindication to local anesthetics used in the study
  • History of diabetes mellitus with neuropathy or other neuropathic disorders
  • Contraindications to regional anesthesia techniques
  • Refusal to participate

Treatment and study plan

Adductor Canal Block (ACB) Only

Procedure

Ultrasound-guided injection of 10 mL 0.25% bupivacaine into the adductor canal targeting the femoral artery region, providing motor-sparing analgesia to the medial/anterior knee.

biceps femoris short head block + Adductor Canal Block (ACB)

Procedure

Combination of adductor canal block (10 mL 0.25% bupivacaine) and biceps femoris short head block with 25 mL 0.25% bupivacaine, deposited at the interfascial plane between BiFeS muscle and lateral femoral cortex to extend analgesia to the posterolateral knee.

Primary outcomes

  1. Total Opioid Consumption (Tramadol, mg)

    Time frame: 24 hours

    The total dose of tramadol administered via intravenous patient-controlled analgesia (PCA) device within the first 24 hours postoperatively will be recorded in milligrams.

Secondary outcomes

  1. Postoperative Pain with Movement and at rest (NRS)

    Time frame: At 0, 6, 12, and 24 hours after surgery

    Pain intensity during knee movement will be assessed using the Numerical Rating Scale (0-10).

  2. Rescue Analgesia Requirement

    Time frame: Within the first 24 hours postoperatively

    The number of patients requiring rescue analgesia (IV dexketoprofen 50 mg) will be recorded.

  3. Incidence of Nausea and Vomiting

    Time frame: Within the first 24 hours postoperatively

    Presence of nausea/vomiting and the requirement for antiemetic medications will be documented.

  4. Quality of Recovery (QOR-15 score)

    Time frame: At 24 hours after surgery

    Patient recovery quality will be assessed using the validated Quality of Recovery 15-item questionnaire (QOR-15). The scale includes 15 items, each scored from 0 to 10, producing a total score ranging from 0 to 150.

    Minimum score: 0 (poor recovery)

    Maximum score: 150 (excellent recovery)

    Interpretation: Higher scores indicate better postoperative recovery.

  5. Dermatomal Spread of Block

    Time frame: 2nd hour postoperatively

    Sensory block distribution will be assessed using a cold test to map dermatomal coverage.

  6. Motor Blockade Incidence

    Time frame: Within the first 24 hours postoperatively

    Patients will be evaluated for presence or absence of motor weakness attributable to the block.

Sponsors and collaborators

Lead sponsor

Kanuni Sultan Suleyman Training and Research Hospital

Other

Registry information

Official study title

Comparison of the Analgesic Efficacy of Adductor Canal Block Versus Adductor Canal Plus Biceps Femoris Short Head Block in Patients Undergoing Knee Arthroscopy: A Prospective Randomized Controlled Trial

Acronym: bifes knee

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Nov 21, 2025
Registry last updated
Apr 7, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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