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NCT Number: NCT07526831

Comparison of the Analgesic Efficacy of Adductor Canal Block and Combined Adductor Canal Block Plus IPACK Block in Knee Surgery

To evaluate the effectiveness of Adductor Canal Block and combined Adductor Canal plus IPACK block in reducing postoperative pain and analgesic requirements in patients undergoing knee surgery.

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Key information

Conditions

Knee Arthroplasty, Total

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Sibel Pehlivan, Kayseri, Talas, Turkey (Türkiye)

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About this study

In total knee arthroplasty, ultrasound-guided Adductor canal block or Adductor Canal block combined with local anesthetic infiltration between the popliteal artery and the capsule of the knee (IPACK) will provide adequate postoperative analgesia.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ASA (American Society of Anesthesiologists) I- ASA II-ASA III Patients

Exclusion criteria

  • history of allergy to the study medication
  • refusal to participate

Treatment and study plan

Adductor Canal Block Group (Group I)

Procedure

All patients in Group I will receive a preoperative adductor canal block. In all groups, an intravenous patient-controlled analgesia device containing morphine will be administered for postoperative pain management.

Adductor Canal + iPACK Block Group (Group II)"

Procedure

All patients in Group II will receive a preoperative adductor canal block combined with an iPACK block. Postoperatively, all patients in both groups will be provided with intravenous patient-controlled analgesia containing morphine for pain management.

Primary outcomes

  1. opioid consumption

    Time frame: 24 hours after surgery

    In the recovery room, all patients will given a patient- controlled analgesia device containing morphine 0.5 mg/ml, set to deliver a 1mg bolus dose of morphine with an 15 min lockout time and 4 mg 1 h limit.Total morphine consumption during the 24 hours postoperative period will recorded at 5 times intervals ( 2, 4, 6, 12, 24 hours).

  2. Verbal analog Pain Scores on rest and movement

    Time frame: 24 hours after surgery

    A Research assistant, blinded to the group allocation, interviewed patients and collected data at 5 times intervals ( 2, 4, 6, 12, 24, hours) in the 24 hours postoperatively. Patients were asked to rate their pain using verbal analog scale, where 0= no pain and 10= worst pain possible.

Secondary outcomes

  1. incidences of adverse effects (like nausea and vomiting)

    Time frame: 24 hours after surgery

    incidences of nausea and vomiting during the 24 hours postoperative period will recorded at 6 time intervals ( 2, 4, 6, 12, 24 hours).

Study contacts

Contact information is provided by the study sponsor or research team.

Sibel Pehlivan, DR

CONTACT

[email protected]

0905052532919

Sponsors and collaborators

Lead sponsor

TC Erciyes University

Other

Registry information

Official study title

Comparison of the Analgesic Efficacy of Adductor Canal Block Versus Adductor Canal Block Combined With Local Anesthetic Infiltration Between the Popliteal Artery and the Capsule of the Knee (IPACK) in Patients Undergoing Knee Surgery

Important dates

Study start
2026
Primary completion
2028
Study completion
2028
First posted
Apr 13, 2026
Registry last updated
May 14, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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