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NCT Number: NCT07542028

Comparison of the Analgesic Effects of TFPB in Renal Transplantation Surgery

Renal transplantation is a major surgical procedure associated with significant postoperative pain, particularly due to lower abdominal incision, deep tissue dissection, and extensive surgical manipulation. Effective postoperative pain control is therefore of great importance in this patient population, as inadequate analgesia may impair early mobilization, delay recovery, increase opioid consumption, and contribute to opioid-related adverse effects. In addition, optimal analgesic management may improve patient comfort and support enhanced postoperative outcomes.

Nerve blocks reduces opioid consumption in the postoperative period by providing better pain control and therefore has advantages such as fewer side effects and less risk of pulmonary and cardiac complications.

In this study; it was aimed to compare the analgesic effectiveness of transversalis fascia plane block in the postoperative period in patients who underwent renal transplantation.

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Key information

Conditions

Renal Transplantation Agnosia Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Pain Management Pathological Conditions, Signs and Symptoms Perceptual Disorders Peripheral Nerve Block Signs and Symptoms

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients aged 18-65 years
  • American Society of Anesthesiologists (ASA) score III
  • Body Mass Index (BMI) between 18-30 kg/m2

Exclusion criteria

  • Patients under 18 and over 65 years of age
  • Patients with an ASA score other than III
  • Patients with a history of bleeding diathesis
  • BMI below 18 or above 30 kg/m2

Treatment and study plan

Transversalis Fascia Plane Block Group

Procedure

This procedure will be performed unilaterally on the surgical side. 30 ml of 0.25% bupivacaine will be injected for ultrasound-guided transversalis fascia plane block application.

The standard intraoperative analgesic regimen will consist of intravenous tramadol (1 mg/kg) administered both before the incision and at the end of the procedure, with intravenous paracetamol (10 mg/kg) given exclusively at the end of the surgery.

Control Group

Procedure

No peripheral nerve block will be performed.

The standard intraoperative analgesic regimen will consist of intravenous tramadol (1 mg/kg) administered both before the incision and at the end of the procedure, with intravenous paracetamol (10 mg/kg) given exclusively at the end of the surgery.

Primary outcomes

  1. Pain Scores

    Time frame: On the operation day

    Pain will be assessed at rest and while coughing using the visual analog scale on a scale from 0 (no pain) to 10 (worst pain). Pain assessment will be done at 1st, 2nd, 4th, 12th, and 24th hours after surgery

Secondary outcomes

  1. Intraoperative opioid consumption

    Time frame: Intraoperative period

    Remifentanil consumption for intraoperative period will be recorded

  2. Postoperative Opioid Consumption

    Time frame: On the operation day

    Opioid consumption for 24 hours will be recorded

Study contacts

Contact information is provided by the study sponsor or research team.

Atakan Sezgi

CONTACT

[email protected]

00905323327000

Jülide Ergil

CONTACT

[email protected]

00905323469216

Sponsors and collaborators

Lead sponsor

Ankara Etlik City Hospital

Other Gov

Registry information

Official study title

Comparison of the Analgesic Effects of Transversalis Fascia Plane Block in Renal Transplantation Surgery

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Apr 21, 2026
Registry last updated
Apr 28, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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