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NCT Number: NCT07326436

Comparison of Sympathetic Blockade Duration in Brachial Plexus Blocks Performed by Different Methods

This prospective comparative study will evaluate the sympathetic effects of ultrasound-guided infraclavicular versus supraclavicular brachial plexus blocks in adults undergoing upper-extremity surgery. Sympathetic tone will be monitored noninvasively with simultaneous bilateral measurements of perfusion index (pulse-oximetry-derived) and skin temperature obtained at baseline and at predefined post-block intervals until return to baseline. The primary outcome is the duration of sympathetic block. Secondary outcomes are between-approach differences in the time course of perfusion index and skin temperature, and the incidence and magnitude of rebound sympathetic activity.

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Key information

Conditions

Anesthesia, Conduction Brachial Plexus Blockade Sympathetic Blockade

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Bozyaka Training and Research Hospital

Izmir, İzmir, 35030, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18 to 65 year old
  • ASA I-II
  • Patients scheduled for upper extremity surgery
  • Fully oriented and able to cooperate
  • Patients who signed the informed consent form and gave consent to participate in the study

Exclusion criteria

  • ASA III-IV-V
  • Non-cooperation
  • Disease that interferes with sensory block assessment
  • Known allergy to the medicines to be used
  • Pregnant patients
  • Coagulopathy or thrombocytopenia
  • Patients with anatomical abnormalities or active infection at the points of application

Treatment and study plan

Supraclavicular brachial plexus block

Procedure

A linear US probe (7-13 MHz) will be placed in the supraclavicular area in the coronal oblique plane, in-plane technique will be used, and after antisepsis of the area to be blocked, injection will be performed from lateral to medial direction using a 22G 50 mm stimulator needle (Stimuplex A®: B. Braun Melsungen AG, Japan). Intermittent negative aspiration will be performed during all procedures to detect possible vascular puncture. A total of 30 mL of 2% prilocaine containing 0.5% bupivacaine and 5 mcg/mL adrenaline in a 1:1 ratio will be used as local anesthetic.

Infraclavicular brachial plexus block

Procedure

A linear US probe (7-13 MHz) will be placed in the infraclavicular area through a lateral sagittal approach, in plane technique will be used and injection will be performed using a 22G 100 mm stimulator needle (Stimuplex A®: B. Braun Melsungen AG, Japan) after antisepsis of the area to be blocked. Intermittent negative aspiration will be performed during all procedures to detect possible vascular puncture. A total of 30 mL of 2% prilocaine containing 0.5% bupivacaine and 5 mcg/mL adrenaline in a 1:1 ratio will be used as local anesthetic.

Primary outcomes

  1. Difference in duration of sympathetic blockade after different US-guided brachial plexus blocks

    Time frame: Twenty-four hours after nerve blockage

Secondary outcomes

  1. Change in perfusion index between infraclavicular and supraclavicular approaches

    Time frame: Twenty-four hours after nerve blockage

    The perfusion index measured by pulse oximetry will be recorded at baseline and twenty-four hours after brachial plexus block. The outcome measure is defined as the change in perfusion index value between the two time points and compared between block approaches.

Sponsors and collaborators

Lead sponsor

Bozyaka Training and Research Hospital

Other

Registry information

Official study title

Comparison of Sympathetic Block Duration and Rebound Sympathetic Activity Rate in Infraclavicular and Supraclavicular Brachial Plexus Blocks Using Perfusion Index and Skin Temperature

Important dates

Study start
2023
Primary completion
2023
Study completion
2023
First posted
Jan 8, 2026
Registry last updated
Jan 8, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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