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OpenTrials
Completed

NCT Number: NCT01777178

Comparison of Standard Versus Low Bicarbonate Hemodialysis

This study will compare acid-base changes during hemodialysis treatments with a standard dialysis bath versus a lower bicarbonate dialysis bath, and aims to define the factors that limit equilibration of the bicarbonate concentration in a patient's blood with that in the dialysate.

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Key information

Conditions

Chronic Kidney Disease Acid-Base Imbalance Acidosis Chronic Disease Disease Attributes Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Metabolic Acidosis Metabolic Diseases Nutritional and Metabolic Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Renal Insufficiency Renal Insufficiency, Chronic Urogenital Diseases Urologic Diseases

Age range

19 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Primary location

Montefiore Medical Center/Jack D. Weiler Hospital

The Bronx, New York, 10461, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Receiving chronic thrice-weekly conventional hemodialysis for at least 3 months
  • Age > 18 years

Exclusion criteria

  • Use of oral alkali within the previous month
  • Hospitalization within the previous month
  • Inability to provide written informed consent
  • Pregnancy

Treatment and study plan

Low bicarbonate dialysis

Other

Primary outcomes

  1. Change in beta-hydroxybutyrate clearance

    Time frame: 1-2 weeks

    Comparison between 2 hemodialysis treatments with different bicarbonate dialysis concentrations

  2. Change in lactate clearance

    Time frame: 1-2 weeks

    Comparison between 2 hemodialysis treatments with different bicarbonate dialysis concentrations

  3. Post-dialysis pH

    Time frame: 1-2 weeks

  4. Post-dialysis bicarbonate

    Time frame: 1-2 weeks

Sponsors and collaborators

Lead sponsor

Albert Einstein College of Medicine

Other

Registry information

Official study title

Intradialytic Acid-base Changes and Organic Anion Production With Standard Versus Low Bicarbonate Hemodialysis

Important dates

Study start
2013
Primary completion
2013
Study completion
2013
First posted
Jan 28, 2013
Registry last updated
Apr 30, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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