Skip to main content
OpenTrials
Completed

NCT Number: NCT05343702

Comparison of Standard rapi̇d Sequential Intubation Protocol With Rocuronium in Emergency Department

Airway management and advanced airway management are the issues that are applied every day in emergency services and that the emergency physician should know best. Rapid sequential intubation is one of the most frequently used techniques in advanced airway management. However, anesthetic agents and paralytic agents have some concerns with some side effects. In our study, This study aimed to compare the effect of standard rapid sequential intubation protocol and application of rocuronium priming technique on the procedure time and hemodynamic profile.

Completed

Looking for future studies?

Notify Me

Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Ankara Bilkent Şehir Hastanesi

Ankara, 0600, Turkey (Türkiye)

About this study

This study is a prospective, observational and randomized study conducted between 15.07.2021 and 01.12.2021 in Ankara City Hospital Emergency Medicine Clinic, which is a third-level emergency department with approximately 450,000 patient admissions per year. Patients who applied to the emergency department and needed rapid sequential intubation were included in our study. Randomization was done according to the order of arrival of the cases. The demographic characteristics of the patients included in the study and the presence of diabetes mellitus were recorded. Routine rapid sequential intubation was performed in the standard group. In the priming group, 10% of the rocuronium dose was administered approximately 3 minutes before the induction agent. Intubation time, amount of drug used, vital signs before and after intubation, and end tidal carbon dioxide level to confirm intubation were recorded.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Be over the age of 18
  • Need for advanced airway
  • To give consent or consent to participate in the study consent of relatives of those who are unable to give

Exclusion criteria

  • Have an indication of a crush (rescue) airway
  • Have one of the difficult airway predictor Look, Evaluate, Obstruction, Neck mobility criteria
  • maxillofacial anomaly or trauma
  • detected during laryngoscopy with a cormack-lehane score of 3 and 4 patients
  • Those who have inconveniences in applying ketamine to the clinic of the patient
  • with a rocuronium or ketamine allergy

Treatment and study plan

priming with rocuronium

Drug

Following induction (paralysis after onset of the induction effect) in routine rapid sequence intubation protocols While paralysis is applied, it is aimed to shorten the half-life of rocuronium by administering a subparalytic dose of rocuronium approximately 3-5 minutes before induction in the priming technique

Primary outcomes

  1. intubation time

    Time frame: ten minutes

    when successful endotracheal intubation is performed after induction

  2. blood pressure systolic and diastolic

    Time frame: ten minutes

    mmhg

  3. heart rate

    Time frame: ten minutes

    beats/minute

Secondary outcomes

  1. indirect perfusion

    Time frame: ten minutes

    Indirect tissue perfusion interpretation with endtidal carbon dioxide levels

Sponsors and collaborators

Lead sponsor

Ankara City Hospital Bilkent

Other

Registry information

Official study title

Comparison of Standard rapi̇d Sequential Intubation Protocol With Rocuronium Priming Technique in Patients Registering to the Emergency Department and With Indication of Elective Intubation

Important dates

Study start
2021
Primary completion
2021
Study completion
2022
First posted
Apr 25, 2022
Registry last updated
Sep 28, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.