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OpenTrials
Completed

NCT Number: NCT06764667

Comparison of Spinal Anesthesia Adjuvant and Quadratus Lumborum Block on the Opioid Requirement and Perioperative Pain of Laparoscopic Kidney Transplant Donor

This study aims to compare the effectiveness of spinal anesthesia adjuvant and quadratus lumborum block on the opioid requirement and perioperative pain on patients undergoing laparoscopic kidney transplant donor.

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Key information

Conditions

Laparoscopic Donor Nephrectomy Perioperative Pain Management

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

RSUP dr. Cipto Mangunkusumo

Jakarta Pusat, Jakarta Special Capital Region, 10430, Indonesia

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients aged 18-65 years undergoing laparoscopic donor nephrectomy
  • Patients with BMI ≤ 35 kg/m2
  • Patients with American Society of Anesthesiology (ASA) physical status 1-2
  • Patients who are willing to participate in this study

Exclusion criteria

  • Cardiovascular disease (uncontrolled stage 2 hypertension, heart failure, arrhytmia)
  • Recent onset cerebrovascular diseasae of < 3 months
  • Infection on spinal site
  • Coagulopathy
  • Elevated intracranial pressure
  • Severe renal or liver dysfunction
  • Valvular heart disease or atrioventricular block

Treatment and study plan

Spinal anesthesia adjuvant

Procedure

Patients in this arm will receive 10 mg 0.5% hyperbaric Bupivacaine, 100 mcg Morphine, 100 mcg Sulfas Atropine, and 0.9% normal saline to total volume of 4 ml before induction of anesthesia.

Quadratus Lumborum Block (QLB)

Procedure

Patients in this arm will receive quadratus lumborum block with 20-30 ml of 0.25% Bupivacaine after induction of anesthesia and after operation.

General Anesthesia

Procedure

The subject will undergo preoxygenation with 100% oxygen for 3 minutes. Following preoxygenation, anesthesia induction will be performed using lidocaine at a dose of 1.5 mg/kg, fentanyl at 1.5 mcg/kg, and propofol at 2.0 mg/kg. Once the subject is adequately sedated, baseline neuromuscular monitoring using the train-of-four (TOF) technique will be conducted, followed by the administration of rocuronium at a dose of 0.8 mg/kg. Endotracheal intubation will be performed using direct laryngoscopy once the TOF value reaches 0, utilizing an appropriately sized endotracheal tube (ETT). Ten milligrams of intravenous dexamethasone is administered after induction.

Primary outcomes

  1. Postoperative pain

    Time frame: Hour 2, 6, 12, and 24

    Postoperative pain measured with Numerical Rating Scale (NRS) during rest and movement.

  2. Opioid requirement

    Time frame: Hour 2, 6, 12, and 24

    Morphine requirement on Patient-Controlled Analgesia (PCA).

Sponsors and collaborators

Lead sponsor

Indonesia University

Other

Collaborators

  • Dr Cipto Mangunkusumo General Hospital

Registry information

Important dates

Study start
2025
Primary completion
2025
Study completion
2026
First posted
Jan 8, 2025
Registry last updated
Jun 8, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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