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NCT Number: NCT07691554

Comparison of Short-Axis and Long-Axis Internal Jugular Vein Cannulation for First-Pass Success

To compare the frequency of first pass success by short axis versus long axis for cannulation of internal jugular vein.

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Key information

Age range

25 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

About this study

This randomized controlled trial aims to compare the effectiveness of short-axis and long-axis ultrasound-guided approaches for cannulation of the internal jugular vein (IJV) in terms of first-pass success. Central venous catheterization is a commonly performed procedure for invasive monitoring and administration of medications and fluids. Ultrasound guidance has improved the safety and success of IJV cannulation compared with traditional landmark-based techniques; however, uncertainty remains regarding the optimal ultrasound imaging approach.

A total of 60 eligible patients undergoing IJV cannulation will be enrolled and randomly allocated into two equal groups. Participants in Group A will undergo ultrasound-guided IJV cannulation using the short-axis approach, while participants in Group B will undergo cannulation using the long-axis approach. All procedures will be performed by the researcher under direct supervision using standardized ultrasound-guided techniques.

The primary objective is to compare the frequency of first-pass success between the two approaches. First-pass success is defined as successful IJV cannulation with a single skin puncture and without needle redirection. Baseline demographic and clinical characteristics will be recorded before the procedure. The findings of this study may help identify the preferred ultrasound-guided technique for maximizing first-pass success during IJV cannulation and potentially reducing procedure-related complications associated with multiple cannulation attempts.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 25-70 years.
  • Either male or female gender.
  • Undergoing cannulation of IJV.

Exclusion criteria

  • Patients who will be on hemodialysis therapy through double lumen catheter in IJV, assessed by reviewing previous medical records.
  • Patients who will have history of previous insertion of IJV line, assessed by reviewing previous medical records.
  • Patients with history of neck surgery, assessed by reviewing previous medical records.
  • Uncooperative patient.
  • Platelet count < 50,000/mm3.
  • International normalized ration 3 times upper normal limit (1.1).

Treatment and study plan

Short-Axis Ultrasound-Guided Internal Jugular Vein Cannulation

Device

Internal jugular vein cannulation performed under ultrasound guidance using the short-axis approach. The transducer is placed in a transverse orientation at the level of the cricoid cartilage, allowing visualization of the internal jugular vein and carotid artery during needle insertion.

Long-Axis Ultrasound-Guided Internal Jugular Vein Cannulation

Device

Internal jugular vein cannulation performed under ultrasound guidance using the long-axis approach. The transducer is rotated to obtain a longitudinal view of the internal jugular vein, allowing continuous visualization of the needle during vessel cannulation.

Primary outcomes

  1. First-Pass Success Rate of Ultrasound-Guided Internal Jugular Vein Cannulation

    Time frame: Assessed during the cannulation procedure (within 5 minutes of initiation of cannulation).

    First-pass success rate of ultrasound-guided internal jugular vein cannulation, defined as successful venous cannulation with a single skin puncture and needle pass.

Secondary outcomes

  1. Total Cannulation Success Rate

    Time frame: Assessed during the procedure (within 15 minutes).

    Total cannulation success rate, defined as successful placement of the internal jugular venous catheter.

  2. Number of Needle Passes Required for Successful Cannulation

    Time frame: Recorded during the procedure.

    Total number of needle insertion attempts required to achieve successful ultrasound-guided internal jugular vein cannulation.

  3. Incidence of Hematoma Formation at the Cannulation Site

    Time frame: Assessed immediately after the procedure and within 24 hours.

    Occurrence of hematoma at the internal jugular vein cannulation site following ultrasound-guided catheter insertion.

  4. Incidence of Posterior Vessel Wall Puncture

    Time frame: Assessed during the procedure.

    Occurrence of unintended puncture of the posterior wall of the internal jugular vein during ultrasound-guided cannulation.

  5. Incidence of Pneumothorax Following Cannulation

    Time frame: Assessed within 24 hours following cannulation.

    Occurrence of pneumothorax associated with ultrasound-guided internal jugular vein cannulation.

  6. Overall Procedure-Related Complications

    Time frame: Assessed during the procedure and up to 24 hours after cannulation.

    Frequency of procedure-related adverse events, including hematoma, posterior vessel wall puncture, pneumothorax, or other complications occurring during or after ultrasound-guided internal jugular vein cannulation.

Study contacts

Contact information is provided by the study sponsor or research team.

Shahida Khawaja, MBBS FCPS

CONTACT

[email protected]

+92 300 8462091

Waleed Noor, MBBS FCPS

CONTACT

[email protected]

+923154960902

Sponsors and collaborators

Lead sponsor

University of Health Sciences Lahore

Other

Registry information

Official study title

Comparison Between Short Axis and Long Axis For Cannulation Of Internal Jugular Vein in Terms Of First Pass Success

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Jul 9, 2026
Registry last updated
Jul 10, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.