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Completed

NCT Number: NCT03807453

Comparison of Scalp Microbiota of the Psoriasis and Seborrheic Dermatitis Patients

A sterile swap specimen taken from the scalp of the patients with psoriasis vulgaris or seborrheic dermatitis and the volunteer control group will be examined in our study. The examples of the microbiota of the patients will be taken both the lesional scalp and the lesion-free part of the scalp. Then, the microbiota differences between the lesioned scalp and the lesion-free scalp of both groups, and the microbiome differences between the two groups and the control group will be evaluated.

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Key information

Conditions

Psoriasis Vulgaris Communicable Diseases Dermatitis Dermatitis, Seborrheic Disease Attributes Infections Microbial Colonization Pathologic Processes Pathological Conditions, Signs and Symptoms Sebaceous Gland Diseases Seborrheic Dermatitis Skin Diseases Skin Diseases, Eczematous Skin Diseases, Papulosquamous Skin and Connective Tissue Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Melek Aslan Kayıran

Istanbul, Turkey (Türkiye)

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with scalp psoriasis
  • Patients with seborrheic dermatitis
  • Agree to participate in research 4 - Do not use any drugs for their disease topically or systemically for two months

Exclusion criteria

  • Patients who do not want to participate in the study
  • Patients with psoriasis vulgaris or seborrheic dermatitis that does not effect scalp.
  • Those with chronic diseases that may affect skin microbiome
  • Patients using antibiotics, antifungal or antiviral therapy for any reason for the last one month.
  • Patients who are using topical or systemic drugs for their illness

Treatment and study plan

Microbiota

Other

The scalp microbiota

Primary outcomes

  1. The scalp microbiota of the patients with psoriasis and seborrheic dermatitis

    Time frame: 6 months

    The aim of this study is to compare the scalp microbiota of psoriasis vulgaris and seborrheic dermatitis both the lesion and lesion-free parts and also the control group and to assess their role on etiopathogenesis. Determining the microbiota of this region which is frequently involved and resistant to treatment may change the treatment approach. In addition, scalp microbiome of seborrheic dermatitis may be a causal factor of rapid relapse after treatment.

    The similarities between the microbiota of the psoriasis vulgaris and seborrheic dermatitis cases with only scalp involvement can guide us not only for the diagnosis but also the treatment. There are a few reports about the role of Malassezia subgroups in the pathogenesis, but it is known that there are many different flora members on the scalp. Exposing these can change both our diagnosis and treatment options.

Secondary outcomes

  1. The differences between the scalp microbiota of different countries

    Time frame: 6 months

    Does the microbiota of the patients change between the countries? To our knowledge, there is no similar studies in present. Presenting the scalp microbiome of Turkish population can be a start to understand whether there is a difference in terms of the countries.

Sponsors and collaborators

Lead sponsor

Istanbul Medeniyet University

Other

Collaborators

  • Turkish Dermatology Association

Registry information

Official study title

Comparison of Scalp Microbiota of the Patients With Psoriasis Vulgaris and Seborrheic Dermatitis

Important dates

Study start
2019
Primary completion
2019
Study completion
2019
First posted
Jan 17, 2019
Registry last updated
Sep 10, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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