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NCT Number: NCT07458139

Comparison of Root Resorption in Modified Corticotomy-Assisted and Conventional Canine Retraction

This randomized controlled clinical trial will compare external apical root resorption in patients undergoing maxillary canine retraction using modified corticotomy-assisted frictionless T-loop mechanics versus conventional frictionless T-loop mechanics. Sixty orthodontic patients requiring extraction of maxillary first premolars will be randomly assigned to two groups. Changes in canine root length will be measured on panoramic radiographs taken before and after retraction to determine the extent of external apical root resorption. The study will evaluate whether modified corticotomy-assisted retraction results in different root resorption outcomes compared to conventional retraction.

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Key information

Age range

12 year–30 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

About this study

External apical root resorption is a known complication of orthodontic treatment and may be influenced by the magnitude and duration of orthodontic force. Methods that accelerate tooth movement may reduce overall treatment time and potentially influence the extent of root resorption.

Corticotomy-assisted orthodontics is based on the regional acceleratory phenomenon, which enhances bone remodeling and facilitates tooth movement. Modified corticotomy techniques involve limited surgical injury to the cortical bone to stimulate accelerated movement while minimizing postoperative morbidity. Frictionless mechanics using T-loops allow controlled canine retraction with reduced frictional resistance between the bracket and archwire.

This single-center randomized controlled clinical trial will enroll 60 patients aged 12 to 30 years who require bilateral extraction of maxillary first premolars as part of orthodontic treatment. Participants will be randomly allocated in a 1:1 ratio to:

Group A: Modified corticotomy-assisted canine retraction with frictionless T-loop mechanics Group B: Conventional frictionless T-loop canine retraction

All participants will be treated using 0.022 × 0.028-inch preadjusted edgewise appliances. Standardized T-loop activation delivering controlled force will be performed at three-week intervals until canine retraction is completed.

External apical root resorption will be assessed by measuring linear changes in root length from the canine cusp tip to the root apex on calibrated pre- and post-retraction panoramic radiographs using digital measurement software. The primary outcome measure will be the mean change in root length between baseline and post-retraction assessments. Statistical analysis will compare the magnitude of root resorption between the two groups.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients aged 12-30 years requiring canine retraction into maxillary first premolar extraction spaces
  • Patients with normal vertical skeletal pattern (mandibular plane angle 32° ± 5°)
  • Patients with healthy periodontium

Exclusion criteria

  • Syndromic patients
  • Patients with systemic conditions requiring long-term medication affecting orthodontic tooth movement (e.g., NSAIDs, bisphosphonates, anticonvulsants)
  • Mixed dentition cases
  • Patients with pre-existing root resorption
  • Patients who fail to attend scheduled appointments

Treatment and study plan

Modified Corticotomy assisted frictionless canine retraction

Procedure

A surgical procedure in which a buccal flap is elevated and two vertical corticotomy cuts are made in the maxillary cortical bone adjacent to the extraction site to accelerate orthodontic tooth movement.

Conventional Frictionless Canine retraction

Procedure

Orthodontic space closure using 17×25 TMA T-loops activated to deliver approximately 200 g of force for frictionless canine retraction into maxillary first premolar extraction spaces.

Primary outcomes

  1. Mean Loss of Canine Root Length (mm)

    Time frame: - Before retraction (baseline) - From baseline to completion of canine retraction (approximately 4-6 months)

    External apical root resorption measured as the difference in root length (in millimeters) from canine cusp tip to root apex on calibrated pre-treatment and post-retraction OPG radiographs using ViewBox software.

Secondary outcomes

  1. Change in Root Width at Mesial and Distal Apex (mm)

    Time frame: From baseline to completion of canine retraction (approximately 4-6 months)

    Difference in mesial and distal root width measured 1 mm short of the root apex on calibrated OPG radiographs before and after canine retraction.

Other outcomes

  1. Degree of External Apical Root Resorption According to Sharpe Classification

    Time frame: At completion of canine retraction (approximately 4-6 months)

    SHARPE ET AL. CLASSIFICATION OF EXTERNAL ROOT RESORPTION

    0 = No apical root resorption

    • Slight blunting of the root apex
    • Moderate resorption of root apex beyond blunting and up to one-third of root length.
    • Excessive (severe) resorption of the root apex beyond one-third of the root length.

Study contacts

Contact information is provided by the study sponsor or research team.

Dr. Menal Khurshid, BDS

CONTACT

[email protected]

0333-5303397

Prof. Dr. Haroon Shahid Qazi, BDS, MS, MCPS (HPE),

CONTACT

[email protected]

0300-5001774

Sponsors and collaborators

Lead sponsor

Islamabad Medical and Dental College

Other

Registry information

Official study title

Comparison of External Apical Root Resorption in Modified Corticotomy-Assisted and Conventionally Retracted Maxillary Canines Using Frictionless T-Loop Mechanics: A Randomized Controlled Clinical Trial

Acronym: MCA-CR

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Mar 9, 2026
Registry last updated
Mar 9, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.