Completed

NCT Number: NCT05280236

Comparison of Quality of Recovery Between Remimazolam and Propofol Anesthesia in Patients Undergoing Arthroscopic Meniscectomy

This study aims to compare quality of recovery after surgery and anesthesia between patients undergoing arthroscopic meniscectomy under general anesthesia with either propofol or remimazolam based total intravenous anesthesia. This study is a randomized trial with a 50% probability of being assigned to either group. Randomization will be done by an anesthesiologist not involved in anesthesia or postoperative outcome assessment. Patients and the investigator in charge of postoperative outcomes assessment will be blinded to group allocation.

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Key information

Conditions

Adult Patients 19 or Older Scheduled for Elective Arthroscopic Meniscectomy

Age range

19 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Yonsei University Health System, Severance Hospital

Seoul, South Korea

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Adult patients 19 or older, ASA class I~III,
scheduled for arthroscopic meniscectomy under general anesthesia and eligible for LMA use.

Exclusion criteria

Patient refusal,
patients unable to read consent form, active URI or uncontrolled asthma,
pneumonia,
history of allergies to propofol or benzodiazepines,
decreased liver or kidney function, heart failure of ejection fraction<55%,
pregnant or breastfeeding patients,
history of substance abuse/addiction

Treatment and study plan

Propofol TIVA

Drug

Patients will receive propofol-based TIVA with propofol and remifentanil TCI (target controlled infusion)

Remimazolam TIVA

Drug

Patients will receive remimazolam-based TIVA with remimazolam infusion and remifentanil TCI

Primary outcomes

Quality of Recovery (QoR)-40 questionnaire

Time frame: Postoperative 24 hours

Quality of recovery assessed with the QoR-40 questionnaire, which is a widely-used, self-rated, self-completed questionnaire for postoperative patients.

Sponsors and collaborators

Lead sponsor

Yonsei University

Other

Registry information

Important dates

Study start: 2022
Primary completion: 2024
Study completion: 2024
First posted: Mar 15, 2022
Registry last updated: Jul 8, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.