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Completed

NCT Number: NCT06035965

Comparison of Quality of Life and Changes Experienced by Patients After Epilepsy Surgery

Epilepsy is one of the most common chronic neurological diseases. According to data from the World Health Organization (WHO), it affects 0.5 to 1% of the population, or around 70 million people world-wide and around 600,000 in France. There are several more or less severe forms of epilepsy depending on the type of epileptic seizures and the frequency of these seizures. About 30% of epileptic patients respond poorly to well-conducted medical treatment, which makes the number of so-called "drug-resistant" patients estimated at between 100,000 and 150,000 patients.

Epilepsy surgery is possible in some cases of drug-resistant epilepsy and can lead to complete seizure control. Beyond the impact on the control of seizures, surgery can have an impact on the lives of patients at the psychological, emotional and cognitive level, with consequences on their socio-professional but also personal life. Thus the impact on the daily life of patients after epilepsy surgery can vary greatly from one patient to another and the personal feelings of operated patients do not always seem to correspond to the objective elements collected by doctors. 2.3 The investigators want to retrospectively assess the satisfaction and quality of life of patients operated on for more than 2 years based on their epileptological results (frequency of seizures).

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Key information

Age range

15 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

CHU de Toulouse

Toulouse, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient operated in the context of epilepsy surgery dating back more than 2 years in the epileptology center of the Toulouse University Hospital.
  • Patient covered by a social security scheme.
  • Patient having given his non-objection to participate in the research.

Exclusion criteria

  • Minor under the age of 15 at the time of the questionnaires.
  • Serious psychiatric pathology unrelated to epilepsy surgery.
  • Severe intellectual disability limiting responses to self-questionnaires.
  • Language barrier.
  • Patients under guardianship and protection of justice.

Treatment and study plan

Epilepsy Surgery Satisfaction Questionnaire (ESSQ-19)

Other

19 items assessing post-surgery satisfaction.

Quality of Life in Epilepsy Inventory (QOLIE-31)

Other

31 items to assess different dimensions of quality of life

Generalized Anxiety Disorder 7 (GAD7)

Other

7 items, rated from 0 to 3, to detect anxiety disorders.

Neurological Disorders Depression Inventory for Epilepsy (NDDI-E)

Other

to screen for depressive disorders

Evaluation of Changes in Daily Life after Epilepsy Surgery (EVOCQUE)

Other

self-questionnaire developed by the Toulouse epileptology team in 2023 for patients who have undergone epilepsy surgery. It aims to collect the feelings of patients concerning the changes induced by surgery in their daily life according to a 7-point Likert scale.

Primary outcomes

  1. Evaluation of the changes felt by patients

    Time frame: 2 years

    Evaluate the changes felt by patients more than 2 years after surgery in the context of drug-resistant epilepsy using a new questionnaire created by the epileptology team of the Toulouse University Hospital. The rating of the responses is distributed between 0 and 100 (0 = very negative change, 50 = no change and 100 = very positive change).

Sponsors and collaborators

Lead sponsor

University Hospital, Toulouse

Other

Registry information

Official study title

Comparison of Quality of Life and Changes Experienced by Patients After Epilepsy Surgery, With Long-term Epileptological Objective Results

Acronym: EPICHANGE

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Sep 13, 2023
Registry last updated
May 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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