Al Azhar University
Cairo, Egypt, 11865
Not Yet Recruiting
NCT Number: NCT07343570
Comparison of Quadratus Lumborum and Combined Groin Nerve Blocks for Postoperative Analgesia After Open Inguinal Hernia Repair.
This double-blind randomized controlled trial aimes to compares two ultrasound-guided regional techniques-lateral quadratus lumborum block versus combined ilio-inguinal/ilio-hypogastric/genitofemoral (II-IH-GFN) block-for postoperative analgesia after elective unilateral open inguinal hernia repair under spinal anesthesia in adults.
Not Yet Recruiting
Trial opening soon.
Get NotifiedKey information
Age range
18 year–75 year
Sex eligibility
All sexes
Study type
Interventional
Phase
Phase 3
Primary location
Who can participate
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- Adults aged 18-75 years.
- ASA physical status I-III.
- Scheduled for elective unilateral open inguinal hernia repair under standardized spinal anesthesia.
- Able to understand and use the Visual Analogue Scale (VAS).
- Provided written informed consent.
Exclusion criteria
- Allergy to local anesthetics.
- Coagulopathy or current use of anticoagulants contraindicating peripheral nerve blocks.
- Infection at the injection site.
- Chronic opioid use (daily opioids >2 weeks) or chronic pain syndromes.
- Body mass index (BMI) >40 kg/m².
- Conversion to other surgery or bilateral repair.
- Pregnant patients.
- Refusal to sign informed consent.
Treatment and study plan
Ultrasound-guided lateral quadratus lumborum block
ProcedureUltrasound-guided lateral quadratus lumborum block. Local anesthetic: 30 ml of (Ropivacaine 0.2%) is injected at the appropriate fascial level.
Combined ilio-inguinal/ilio-hypogastric/genitofemoral (II-IH-GFN) block
ProcedureUltrasound-guided ilio-inguinal and ilio-hypogastric block. Local anesthesia: 20 ml of 0.2% ropivacaine for ilio-inguinal and ilio-hypogastric block + 10 ml of 0.2% ropivacaine for genitofemoral anaesthesia, total injection volume = 30 ml.
Primary outcomes
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Cumulative opioid consumption in the first 24 hours postoperatively
Time frame: 24 hours after surgery.
Measures the total amount of opioid analgesics (expressed as morphine milligram equivalents, MME) consumed during the first postoperative 24 hours. It reflects overall analgesic efficacy of the two block techniques.
Secondary outcomes
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Pain intensity (VAS pain scores at rest )
Time frame: 24 hours postoperatively.
Assesses the level of postoperative pain at rest using the Visual Analogue Scale (VAS), where 0 = no pain and 10 = worst imaginable pain.
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Pain intensity (VAS pain scores at movement)
Time frame: 24 hours postoperatively.
Assesses the level of postoperative pain during movement using the Visual Analogue Scale (VAS), where 0 = no pain and 10 = worst imaginable pain.
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Time to first analgesic request
Time frame: 24 hours.
Determines the duration of effective analgesia provided by each block, defined as the interval from completion of the block to the first patient request for additional analgesia.
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Proportion of patients requiring rescue opioid analgesia
Time frame: 24 hours.
Percentage of patients who required additional opioid analgesics beyond the planned postoperative regimen, indicating inadequate analgesia from the primary block.
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Incidence of postoperative block-related complications
Time frame: 24 hours.
Evaluates safety of the blocks by recording complications such as hematoma, local anesthetic toxicity, or impaired mobility.
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Patient satisfaction score
Time frame: Assessed at 24 hours postoperatively.
Patient satisfaction with postoperative pain control will be evaluated using a 5-point Likert scale, allowing a simple yet reliable measure of the patient's overall analgesic experience. Each participant will rate their satisfaction as follows: 1 for "very dissatisfied," indicating poor pain relief and marked discomfort; 2 for "dissatisfied," reflecting inadequate but tolerable pain control; 3 for "neutral," representing acceptable analgesia without a clear sense of satisfaction; 4 for "satisfied," denoting good pain relief and minimal discomfort; and 5 for "very satisfied," corresponding to excellent pain control and full contentment with the postoperative analgesia regimen.
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Post-anesthesia care unit (PACU) stay duration
Time frame: 24 hours
Measures the time spent in the PACU
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Total hospital stay duration
Time frame: 24 hours
Measures total length of hospital stay.
Study contacts
Contact information is provided by the study sponsor or research team.
Sponsors and collaborators
Lead sponsor
Al-Azhar University
Other
Collaborators
- Benha University
Registry information
Official study title
Comparing Ultrasound-guided Lateral Quadratus Lumborum Block Versus Combined Ilio-inguinal/Ilio-hypogastric /Genitofemoral Block for Postoperative Analgesia After Open Inguinal Hernia Repair: A Double-blind Randomized Controlled Trial
Important dates
- Study start
- 2026
- Primary completion
- 2026
- Study completion
- 2026
- First posted
- Jan 15, 2026
- Registry last updated
- Jan 15, 2026
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.