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NCT Number: NCT07742826

Comparison of PRF and Corticosteroids in Impacted Third Molar Surgery

This prospective, randomized interventional study aims to compare the postoperative effects of standard treatment (control), platelet-rich fibrin (PRF), and PRF combined with corticosteroid treatment in patients undergoing impacted mandibular third molar surgery. A total of 60 participants will be randomly assigned to one of three treatment groups according to the study protocol. Postoperative pain, facial swelling, and trismus will be evaluated on postoperative days 1, 2, 3, and 7. The findings of this study are expected to provide evidence regarding the effectiveness of PRF alone and PRF combined with corticosteroid treatment in reducing postoperative complications following impacted mandibular third molar surgery.

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Key information

Conditions

Impacted Mandibular Third Molar Extraction Impacted Lower Third Molar Impacted Wisdom Tooth Nervous System Diseases Neurologic Manifestations Neuromuscular Manifestations Pain Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Signs and Symptoms Spasm Trismus

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Final International University Faculty of Dentistry

Nicosia, 2323, Cyprus

Location status: Recruiting

Location contact

Meliz Kneebone, DDS

CONTACT

[email protected]

+905338425731

Meliz Kneebone, DDS

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients aged 18 years and older.
  • Patients with good general health
  • Patients with complete clinical and radiographic examination (panoramic radiograph/CBCT if applicable)
  • Patients willing and able to attend all postoperative follow-up visits

Exclusion criteria

  • Patients with systemic diseases that may impair wound healing (e.g., uncontrolled diabetes, immunodeficiency).
  • Pregnant or breastfeeding women.
  • Patients with acute infection, abscess, or pericoronitis at the surgical site.
  • Patients with a history of allergy or contraindication to corticosteroids, local anesthetics, or prescribed medications.
  • Patients using corticosteroids, anticoagulants, immunosuppressive drugs, or bisphosphonates.
  • Patients with bleeding disorders.
  • Patients with previous radiotherapy to the head and neck region.
  • Patients unable or unwilling to comply with the study protocol or attend follow-up visits.

Treatment and study plan

Platelet-rich fibrin (PRF)

Biological

Autologous platelet-rich fibrin (PRF) prepared from the participant's venous blood by centrifugation at 3000 rpm for 10 minutes, and then placed into the extraction socket immediately after impacted mandibular third molar surgery.

Dexamethasone

Drug

Dexamethasone (8 mg/2 mL) administered as a single intramuscular injection immediately after impacted mandibular third molar surgery in addition to platelet-rich fibrin (PRF), according to the study protocol.

Amoxicillin/clavulanic acid

Drug

Amoxicillin/clavulanic acid administered postoperatively according to the study protocol.

Paracetamol

Drug

Paracetamol 500 mg tablets administered postoperatively for pain control according to the study protocol.

Chlorhexidine

Drug

Chlorhexidine mouthwash administered postoperatively according to the study protocol.

Primary outcomes

  1. Postoperative Pain

    Time frame: Postoperative Days 1, 2, 3, and 7

    Postoperative pain assessed using a 10-cm Visual Analog Scale (VAS), where 0 indicates no pain and 10 indicates the worst pain imaginable.

  2. Postoperative Swelling

    Time frame: Postoperative Days 1, 2, 3, and 7

    Postoperative facial swelling assessed using a flexible measuring tape by recording the linear distances from the tragus to the pogonion (chin point), the tragus to the corner of the mouth, and the lateral canthus of the eye to the angle of the mandible.

  3. Trismus

    Time frame: Postoperative Days 1, 2, 3, and 7

    Trismus assessed by measuring the maximum interincisal mouth opening (mm) using a digital caliper.

Study contacts

Contact information is provided by the study sponsor or research team.

Meliz Kneebone, DDS

CONTACT

[email protected]

+905338425731

Sponsors and collaborators

Lead sponsor

Final International University

Other

Registry information

Official study title

Comparison of Postoperative Effects of PRF and Corticosteroid Treatments in Impacted Third Molar Surgery

Important dates

Study start
2024
Primary completion
2026
Study completion
2026
First posted
Aug 3, 2026
Registry last updated
Aug 3, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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