Comparison of PRESBYOND Laser Blended Vision and Conventional Monovision LASIK in Individuals With Presbyopia: A Randomized Clinical Study

Presbyopia is an age-related condition that causes difficulty seeing at near distance and often leads to visual fatigue and dependence on reading glasses. Corneal refractive surgery has become an option for presbyopia correction. Traditional monovision LASIK corrects one eye for distance and the other eye for near vision, but some people may experience reduced depth perception or visual discomfort. Laser blended vision (LBV) is a modified LASIK technique designed to increase depth of focus and improve vision at multiple distances while maintaining binocular visual function. However, high-quality randomized clinical trials comparing LBV with traditional monovision LASIK are limited.

The purpose of this study is to compare the visual outcomes and safety of laser blended vision and traditional monovision LASIK in adults with presbyopia.

This study is a single-center, randomized, parallel-group clinical trial. About 100 participants aged 40 to 55 years who are suitable for LASIK surgery will be enrolled. Participants will be randomly assigned in a one-to-one ratio to receive either laser blended vision or traditional monovision LASIK.

All surgeries will be performed using standard LASIK procedures by experienced surgeons. Participants will undergo routine eye examinations before surgery and will be followed after surgery at scheduled visits, including 1 week, 1 month, 3 months, and 6 months.

The main evaluation will assess whether participants achieve good uncorrected distance, intermediate, and near vision at 6 months after surgery. Additional assessments will include refractive accuracy, visual quality, stereopsis, contrast sensitivity, patient-reported visual function, and safety outcomes.

Inclusion criteria

• Adults aged 40 to 55 years with presbyopia
• Suitable candidates for LASIK surgery based on clinical evaluation
• Stable refractive status for at least 1 year
• Best corrected distance visual acuity within normal range
• Willing and able to provide written informed consent
• Willing to comply with study visits and follow-up

Exclusion criteria

• Previous ocular surgery
• Corneal disease or abnormal corneal condition that may affect safety
• Significant ocular disease affecting visual function
• Severe dry eye or other ocular surface disorders
• Systemic disease that may affect study participation
• Inability to tolerate monovision or anisometropia
• Any condition that the investigator considers unsuitable for the study