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Completed

NCT Number: NCT06997536

Comparison of Postoperative Analgesic Efficacy of Ultrasound-Guided Ilioinguinal-Iliohypogastric Block, Transversus Abdominis Plane Block, and Quadratus Lumborum Block in Inguinal Hernia Surgery

Inguinal hernia is a common condition, particularly among male patients, and represents one of the most frequent indications for lower abdominal surgeries. Postoperative acute pain and, more importantly, the progression of acute pain into chronic pain, remain significant challenges in the postoperative period. Effective postoperative pain management is therefore crucial in inguinal hernia repair.

In addition to systemic analgesia, various regional anesthesia techniques are employed in this setting. In recent years, peripheral nerve blocks such as the ilioinguinal-iliohypogastric (IL/IH) block, transversus abdominis plane (TAP) block, and quadratus lumborum block (QLB) have gained popularity for postoperative analgesia. These techniques offer several advantages, including reduced opioid consumption and decreased need for additional analgesics, while also minimizing hemodynamic instability and facilitating early mobilization.

The IL/IH block is performed by injecting a local anesthetic into the fascial plane between the transversus abdominis and internal oblique muscles, targeting the ilioinguinal and iliohypogastric nerves, which are branches of the L1 spinal nerve. The TAP block, first described by Rafi in 2001, involves injecting local anesthetic into the fascial plane between the internal oblique and transversus abdominis muscles within the Petit triangle, where the T6-T11 spinal nerve branches responsible for abdominal wall innervation are located. The quadratus lumborum block (QLB) was initially described by Blanco. The first version, known as QLB1, involves posterior injection of local anesthetic lateral to the quadratus lumborum muscle. In 2013, Jens Børglum introduced the transmuscular variant (QLB3), where the local anesthetic is administered between the quadratus lumborum and psoas muscles.

In this study, we aimed to compare postoperative outcomes in patients undergoing inguinal hernia repair under spinal anesthesia, with and without additional peripheral nerve blocks (IL/IH block, TAP block, and QLB). Specifically, we evaluated pain levels using the Visual Analog Scale (VAS) at the 30th minute, 2nd, 6th, 12th, and 24th hours postoperatively. We also assessed opioid-related side effects such as nausea and vomiting associated with patient-controlled analgesia (PCA) using tramadol, the total bolus and infusion doses of tramadol administered, and the amount of additional analgesia in the form of paracetamol. These outcomes were compared among the different block groups and with a control group that received only spinal anesthesia without any additional block.

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Key information

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients classified as ASA I and II
  • Patients aged 18 to 75 years
  • Patients undergoing unilateral inguinal hernia surgery under spinal anesthesia

Exclusion criteria

  • Patients with preoperative neurological sequelae
  • Patients with a BMI >30
  • Patients who refused to participate in the study

Treatment and study plan

Ilioinguinal/iliohypogastric Nerve Block

Procedure

The aim of this study is to compare the analgesic efficacy of IL/IH block, TAP block, and QLB applied in inguinal hernia cases operated under spinal anesthesia, with each other and with a control group that did not receive any additional block to spinal anesthesia.

Transversus abdominis plane (TAP) block

Procedure

The aim of this study is to compare the analgesic efficacy of IL/IH block, TAP block, and QLB applied in inguinal hernia cases operated under spinal anesthesia, with each other and with a control group that did not receive any additional block to spinal anesthesia.

Quadratus Lumborum Block (QLB)

Procedure

The aim of this study is to compare the analgesic efficacy of IL/IH block, TAP block, and QLB applied in inguinal hernia cases operated under spinal anesthesia, with each other and with a control group that did not receive any additional block to spinal anesthesia.

Primary outcomes

  1. Postoperative Pain Score

    Time frame: Postoperative 30th minute, 2nd, 6th, 12th and 24th hours

    Postoperative pain will be assessed using a Visual Analog Scale (VAS) ranging from 0 (no pain) to 10 (the worst imaginable pain). Pain scores will be recorded at predefined time points during rest and movement.

Secondary outcomes

  1. Total Opioid Consumption at 24 Hours.

    Time frame: At the end of the 24th hour

    For patient-controlled analgesia, tramadol 300 mg was prepared in 100 cc of isotonic saline with a concentration of 3 mg/cc. The infusion rate was set at 3 mL/hour, with a 5 mL bolus dose, a lock-out time of 4 hours, and the device was set to be used for 24 hours. In patients with a VAS score of 4 or higher despite opioid demand from the patient-controlled analgesia device, an additional 1 gram of IV paracetamol was planned to be administered as an adjunct analgesic. Total infusion and bolus doses of tramadol over 24 hours were recorded.

Other outcomes

  1. Total nausea and vomiting count over 24 hours

    Time frame: At the end of the 24th hour

    The number of nausea and vomiting episodes experienced by the patients over 24 hours was recorded.

  2. Need for additional analgesia

    Time frame: At the end of the 24th hour

    In patients with a VAS score of 4 or higher despite opioid requests via the patient-controlled analgesia device, 1 gram of IV paracetamol was planned to be administered as an additional analgesic. At the end of the 24th postoperative hour, the total need for additional analgesia was recorded.

Sponsors and collaborators

Lead sponsor

Namik Kemal University

Other

Registry information

Official study title

Comparison of Postoperative Analgesic Efficacy of Ultrasound-Guided Ilioinguinal-Iliohypogastric Block, Transversus Abdominis Plane Block, and Quadratus Lumborum Block in Inguinal Hernia Surgery: A Prospective, Randomized Controlled Trial

Important dates

Study start
2022
Primary completion
2023
Study completion
2024
First posted
May 30, 2025
Registry last updated
May 30, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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