Comparison of Post Tooth Extraction Healing Using Different Xenograft Materials

This is a pilot prospective clinical trial in which histological and micro CT analysis will be utilized to compare between Endobon®, Equimatrix®, and Bio-Oss®.

Primary aim: Compare the percentage of newly formed bone between Equimatrix®, Bio-Oss® and Endobon®.

The investigators hypothesize that the mean percentage of newly formed bone from Equimatrix® will be higher than Bio-Oss® and/or Endobon®.

Secondary aim: Compare the bone density between Equimatrix®, Bio-Oss® and Endobon®.

The investigators hypothesize that the bone density from Equimatrix® will be higher than Bio-Oss® and/or Endobon®.

Inclusion criteria

• Non-restorable single rooted tooth in anterior or premolar region
• Patient previously treatment planned for implant procedure and implant restoration.
• > 10 mm from maxillary sinus or inferior alveolar canal (IAC)
• Intact buccal bone (only minor dehiscence or fenestrations (approximately < 50% of socket depth) can be accepted
• Non-smokers.
• Patients treatment planned for extraction and ridge preservation at Tufts University School of Dental Medicine.

Exclusion criteria

• Poor oral hygiene (plaque index>30%).
• Systemic diseases that affect bone metabolism:

i. Osteoporosis ii. Osteomalacia iii. Hyperthyroidism iv. Hyperparathyroidism v. Paget's disease

• Inflammatory and autoimmune diseases of the oral cavity (severe bone loss) (self-report):

i. Severe chronic periodontitis ii. Aggressive periodontitis iii. Necrotizing ulcerative periodontitis iv. Crohn's disease v. Multiple sclerosis vi. Rheumatoid arthritis vii. Systemic lupus erythematosus

• History of radiation to the head and neck, and /or chemotherapy.
• Current corticosteroid therapy.
• History of IV Bisphosphonates therapy or >3 years of oral intake.
• Infectious diseases such as HIV, tuberculosis, Hepatitis (self-report).
• Known allergy to research related materials.
• Self-reported pregnancy or lactation