Comparison of Post-operative Pain After… | Clinical Trial

Key information

Conditions

Irriversible Pulpitis Activation, Patient Behavior Health Behavior Irrigation Patient Acceptance of Health Care Patient Participation Treatment Adherence and Compliance

Age range

20 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

To compare mean post-operative pain intensity at different time intervals (24h and 48h) using visual analogue scale (VAS) in maxillary incisors with symptomatic irreversible pulpitis using two different irrigation activation methods (passive ultrasonic activation and sonic activation using EndoActivator).

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

• Patients in good health with no systemic disease (ASA Class I or II)

Age range is between 20 to 50 years.
Patients diagnosed with symptomatic irreversible pulpitis in maxillary incisor teeth.
Patients who can understand VAS.
Patients who give verbal consent to participate voluntarily in the study.

Exclusion criteria

• History of systemic disorder.

Pregnant / lactating females (As per medical record/verbally)
Patients who had taken preoperative drugs as anti-inflammatory analgesic or antibiotics.
Patients with swelling or acute peri-apical abscess.
Tooth not suitable for restoration.
Periodontally compromised teeth.
Retreatment cases.

Treatment and study plan

passive ultrasonic activation

Procedure

passive ultrasonic irrigant activation will be performed by using a stainless steel ultrasonic Irrisafe file of size 20 (IRRI S 21/25; VDW, Germany) mounted on ultrasonic unit (Woodpecker Ultrasonic Scaler UDS-J). The file will be kept 2 mm short of working length loosely without binding to the canal. 2.5% NaOCl will be activated for 30 seconds by using a power setting of five

Sonic Activation

Procedure

root canals will be filled with 2.5% sodium hypochlorite and medium size tip (red, 25/04) of EndoAcivator (YAHOPE A3, China) will be used keeping it 2 mm short of working length. The activation of irrigant will be done in 2-3 mm vertical strokes for 30 seconds in between each instrumentation

Primary outcomes

pain score on visual analogue scale

Time frame: 48 hours

After complete root canal irrigation and preparation, canals will be dried and a temporary dressing of Cavit will be placed. Patients will be reappointed for obturation. VAS scale ranging from 0-10 will be given to patient and will be demonstrated on how to record their pain and which will be recorded by the patient after 24 hours and 48 hours by marking on a chart ranging from 0-10 with 0 = no pain, 1-3 = mild pain, 4-6 = moderate pain 7-10 = severe pain. On 5th day of follow-up, obturation will be done using single cone obturation method

Sponsors and collaborators

Lead sponsor

RANA AHMAD

Other

Registry information

Official study title

Comparison of Post-operative Pain After Different Root Canal Irrigant Activation Methods in Maxillary Incisors With Symptomatic Irreversible Pulpitis

Important dates

Study start: 2026
Primary completion: 2026
Study completion: 2027
First posted: Sep 29, 2025
Registry last updated: Sep 29, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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