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NCT Number: NCT02997254

COMparison of Physiological Algorithms for Real-time Evaluation of Atrial Fibrillation

This is a cohort study to evaluate algorithms for mapping atrial fibrillation by mapping atrial structure and mapping electrical activity to detect physiologically important areas.

A key innovation of the observation study is to assess tracking of physiological activity in AF, in relation to tissue activity (MAP recordings), and in relation to AF waves of activity.

This observational work extends prior studies that focused on focal and rotational activity, dispersion of electrical activity, low voltage activity and others.

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Key information

Conditions

Atrial Fibrillation Abnormal Heart Rhythms Arrhythmias, Cardiac Cardiovascular Diseases Heart Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

21 year–90 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Stanford University

Stanford, California, 94305, United States

Location status: Recruiting

Location contact

Gerri O'Riordan, RN

CONTACT

[email protected]

650/725-5597

About this study

In this study, the investigators will compare mapping approaches for atrial fibrillation ablation.

First, investigators will compare approaches to map atrial structure from collected computed tomography (CT) scans or magnetic resonance imaging (MRI) scans acquired routinely in patients undergoing ablation for atrial fibrillation. Imaging will be acquired from a variety of clinically approved

Second, investigators will compare approaches to analyze electrograms collected routinely at clinical electrophysiology study (EPS) in patients undergoing ablation for atrial fibrillation. Electrograms will be recorded from a variety of clinically approved catheters under standard of care conditions, and will be analyzed to better understand the mechanisms for atrial fibrillation and its relationship to outcomes. Electrograms include unipolar recordings, bipolar recordings and, monophasic action potential recordings using FDA-cleared catheters.

The investigators anticipate analyzing data from 1000 patients from inception of the study.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • aged 21-80 yrs who underwent electrophysiology study for ablation of Atrial Fibrillation

Exclusion criteria

  • Poor data quality of recordings of AF

Treatment and study plan

Primary outcomes

  1. Diagnostic Accuracy

    Time frame: At the time of procedure

    Comparing electrogram analysis systems to diagnose sites of importance in Atrial Fibrillation

  2. Diagnostic Accuracy

    Time frame: At time of procedure.

    Comparing algorithms to segment atrial structures from computed tomography or Magnetic resonance images.

Secondary outcomes

  1. Analysis Time

    Time frame: At time of procedure.

    Comparing time required to segment atrial structures from computed tomography or magnetic resonance images.

Study contacts

Contact information is provided by the study sponsor or research team.

Kathleen C Mills, BA

CONTACT

[email protected]

(650) 723-9363

Sanjiv M Narayan, MD, PhD

CONTACT

[email protected]

(650) 723-9363

Sponsors and collaborators

Lead sponsor

Stanford University

Other

Registry information

Acronym: COMPARE_AF

Important dates

Study start
2016
Primary completion
2026
Study completion
2027
First posted
Dec 20, 2016
Registry last updated
Nov 14, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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