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NCT Number: NCT00956423

Comparison of Physical Activity Regimens as Treatments for Obstructive Sleep Apnea

The purpose of this study is to compare the efficacy of two different physical activity regimens as complementary or alternative treatment options for the treatment of obstructive sleep apnea. A secondary purpose of the study is to examine the effects of these activity regimens on various health consequences of obstructive sleep apnea, including blood pressure, systemic inflammation, and daytime functioning.

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Key information

Conditions

Obstructive Sleep Apnea Apnea Dyssomnias Nervous System Diseases Respiration Disorders Respiratory Tract Diseases Sleep Apnea Syndromes Sleep Apnea, Obstructive Sleep Disorders, Intrinsic Sleep Wake Disorders

Age range

18 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1 / Phase 2

Primary location

University of South Carolina, Columbia, South Carolina, United States

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Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • moderate-intensity obstructive sleep apnea (AHI >= 15)
  • sedentary status

Exclusion criteria

  • current treatment for obstructive sleep apnea (CPAP, oral devices, etc.)
  • significant cardiovascular, pulmonary, or metabolic disease
  • uncontrolled hypertension
  • inability to exercise (e.g., musculoskeletal, neuromuscular, orthopedic problems)

Treatment and study plan

moderate-intensity aerobic and resistance training

Behavioral

Individuals will complete four days of aerobic exercise of moderate intensity (60% of maximal VO2, approximated from heart rate). Duration of aerobic activity will gradually increase from weeks 1 through 4 until 180 min of aerobic exercise at the prescribed intensity is performed each week. Following aerobic exercise on two days per week, moderate-intensity resistance training will be performed using eight different resistance machines. One set of 8-12 repetitions will be performed during weeks 1-4; from week 5-on, 2 sets of 8-12 repetitions will be performed.

low-intensity stretching

Behavioral

Individuals will perform supervised whole-body flexibility exercises on two days per week. Two sets of each exercise will be performed, with the duration of each stretch gradually increasing from 15 sec to 30 sec. A total of 15-20 stretches, focusing on whole-body flexibility, will be performed.

Primary outcomes

  1. Laboratory polysomnographic assessment of apnea-hypopnea index

    Time frame: pre- and post-intervention (12 weeks later)

Sponsors and collaborators

Lead sponsor

University of South Carolina

Other

Registry information

Official study title

Exercise: A Novel Treatment for Obstructive Sleep Apnea

Important dates

Study start
2009
Primary completion
2011
Study completion
2011
First posted
Aug 11, 2009
Registry last updated
Nov 24, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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