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NCT Number: NCT06896929

Comparison of Permethrin and Ivermectin in Children Greater Than 6 Yrs Age for Treatment of Scabies

Scabies is highly contagious,pruritic infestation of skin.Various treatment modalities have been used but search for ideal scabicide is ongoing.we wnt to coduct this study to compare the outcome of permethrin verses ivermectin in children for treatment of scabies .This randomized clinical trial will be done in children hospital lahore for 12 months.Sample size of 90 cases;30 in each group will be included through non probability consecutive sampling.Then patient will be randomly divided into 3 groups.In group A patient will be given 5% permethrin topical application to whole body single application. In Group B ,patients will be given topical permethrin for twice application 24 hrs appart ,In group C patients will be given Tablet Ivermectin single dose 200microgram/kg.Then patients will be examined after 2 weeks and 4 weeks for no of lesions and pruritis and cure will be labeled.All this information will be recorded on performa .Data will be entered and analysed by using SPSS version 26.Three groups will be compared for cure by using chi-square test.P value less than and equal to 0.05 will be considered as significant.

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Key information

Age range

6 year–15 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Primary location

Children Hospital Lahore

Lahore, Punjab Province, Pakistan

Location contact

Sadaf Wazir, MBBs

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 6-15
  • Both genders
  • Diagnosed with scabies (as per operational definition)

Exclusion criteria

  • Children with recurrent scabies on medical record
  • Known allergy to ivermectin or permethrin.
  • Widespread eczema or impetigo.
  • Liver dysfunction or renal failure

Treatment and study plan

Permethrin Cream, 5%

Drug

Permethrin 5% cream will be given as a single application

Ivermectin 200 µg/kg

Drug

Group C will be given Tab Ivermectin

Primary outcomes

  1. Cure of scabies.

    Time frame: 12 months

    Cure will be labeled if greater han 50% reduction in no of lesions and pruritis observed after 4 weeks of treatment.

Study contacts

Contact information is provided by the study sponsor or research team.

Sadaf Wazir, MBBs

CONTACT

[email protected]

97403284231293

Sponsors and collaborators

Lead sponsor

Children Hospital and Institute of Child Health, Lahore

Other

Registry information

Official study title

Comparison of Topical Permethrin 1 Day Verses 2 Day Application Versus Oral Ivermectin for Treatment of Scabies in Children Greater Than 6 Yrs of Age

Acronym: not existed

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Mar 26, 2025
Registry last updated
Apr 20, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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