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Completed

NCT Number: NCT07199673

Comparison of Outcome of Injection Sclerotherapy Versus Rubber Band Ligation for Second Degree Hemorrhoids

Objective of this study is to compare the outcome of Injection Sclerotherapy versus Rubber Band Ligation for second degree hemorrhoids in terms of bleeding and efficacy.

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Key information

Conditions

Hemorrhoid Cardiovascular Diseases Digestive System Diseases Gastrointestinal Diseases Hemorrhoids Intestinal Diseases Rectal Diseases Vascular Diseases

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Gulab devi Hospital Lahore

Lahore, Punjab Province, 54600, Pakistan

About this study

There is a difference in the outcome of Injection Sclerotherapy versus Rubber Band Ligation for second degree hemorrhoids in terms of bleeding and efficacy.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults aged between 18 and 75 who have been diagnosed with second-degree hemorrhoids

Exclusion criteria

  • Patients with thrombosed hemorrhoids, and those with serious comorbid conditions such as heart, kidney, or liver diseases, coagulation disorders, or severe anemia.
  • Individuals who have received treatment for hemorrhoids in the past six months.
  • Pregnant women.
  • Patients unable to commit to necessary follow-up appointments.
  • Patients with a history or current presence of colorectal cancer or anal malignancy.

Treatment and study plan

Injection Sclerotherapy

Drug

identifying the hemorrhoidal pedicle, 3-5 ml of 5% phenol in almond oil is injected into the submucosal plane of the hemorrhoid pedicle

Rubber Band Ligation

Device

knee-elbow position is used. After identifying the hemorrhoids with a proctoscope, a rubber band is applied at the base of each hemorrhoid using Barron's Gun and Elise's tissue forceps.

Primary outcomes

  1. Early per rectal Bleeding

    Time frame: 24 hours

    within 24 hours post-procedure

Secondary outcomes

  1. Delayed Bleeding Per rectal

    Time frame: 24 hours to 14th post operative day

    24 hours to 14th post-operative day

Sponsors and collaborators

Lead sponsor

Gulab Devi Hospital

Other

Registry information

Official study title

Comparison of Injection Sclerotherapy and Rubber Band Ligation in Second-Degree Hemorrhoids: A Randomized Controlled Trial

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Sep 30, 2025
Registry last updated
Jun 9, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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