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OpenTrials
Completed

NCT Number: NCT05120999

Comparison of Onset of Neuromuscular Blockade With Electromyographic and Acceleromyographic Monitoring

The purpose of this research is to use 2 devices to compare the difference in the amount of time it takes for each device to register complete muscle relaxation after the muscle relaxing medication is given. The comparison will be made by using electromyographic (EMG), such as TetraGraph, and acceloromyographic (AMG), such as TOFScan, monitors at the time of insertion of breathing tube.

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Key information

Conditions

Neuromuscular Blockade

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Mayo Clinic in Florida

Jacksonville, Florida, 32224, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients willing to participate and provide an informed consent.
  • Patients undergoing elective surgical procedures that require use of NMBA agents (rocuronium) administered intraoperatively.

Exclusion criteria

  • Patients with disorders, such as stroke, carpal tunnel syndrome, broken wrist with nerve damage, Dupuytren contracture, or any similar wrist injury.
  • Patients with systemic neuromuscular diseases such as myasthenia gravis.
  • Patients with significant organ dysfunction that can significantly affect pharmacokinetics of neuromuscular blocking and reversal agents; i.e., severe renal impairment or end-stage liver disease.
  • Patients having surgery that would involve prepping the arm into the sterile field.
  • Patients receiving a rapid sequence induction.

Treatment and study plan

Train of four measurement

Device

Use of either TetraGraph or TOFScan to measure the neuromuscular blockade

Primary outcomes

  1. Time difference

    Time frame: During the initiation of anesthesia period

    Compare time difference from neuromuscular blockade agent administration to neuromuscular blockade onset

Secondary outcomes

  1. Intubating conditions

    Time frame: During the initiation of anesthesia period

    Assess intubating conditions once a complete neuromuscular blockade has been achieved either by TetraGraph or TOFScan measurements

Sponsors and collaborators

Lead sponsor

Mayo Clinic

Other

Registry information

Official study title

Comparison of Onset of Neuromuscular Blockade With Electromyographic and Acceleromyographic Monitoring: A Prospective, Randomized Trial

Important dates

Study start
2021
Primary completion
2022
Study completion
2022
First posted
Nov 16, 2021
Registry last updated
Aug 8, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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