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Completed

NCT Number: NCT00803517

Comparison of Multifocal Electroretinogram Assessment in Chronic Central Serous Chorioretinopathy (CSC) Between Laser Treatment Group and Photodynamic Therapy Group in Chronic Central Serous Chorioretinopathy

This study is a comparison of multifocal electroretinogram assessment between the laser treatment group and the photodynamic therapy group in chronic central serous chorioretinopathy.

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Key information

Conditions

Central Serous Chorioretinopathy Eye Diseases Retinal Diseases

Age range

20 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Samsung Medical Center

Seoul, 135-710, South Korea

About this study

  • Laser Group: extrafoveal focal leakage on FAG
  • PDT Group: no definite focal leak on FAG subfoveal or juxtafoveal focal leakage on FAG, or serous retinal pigmentary epithelial detachment involving foveal center

Inclusion criteria

  • Chronic serous chorioretinopathy (over 3 months) when subretinal fluid persisted in the subfoveal region demonstrated by clinical examination and OCT
  • Ability to maintain steady fixation for mfERG
  • Presence of abnormal dilated choroidal vasculature in ICGA
  • Symptom duration over 3 months

Exclusion criteria

  • previous PDT or laser treatment history
  • evidence of Choriinal neovascularization in FAG
  • other chorioretinal disorders that can cause macular exudation such as age-related macular degeneration, pathologic myopia, angioid streaks, trauma, inflammatory diseases, retinal vasculopathies, and hereditary dystrophies

follow-up Visit

1)baseline 2)1month 3)3months 4)6 months

each visit: multifocal electroretinogram, visual acuity, optical coference timography should be measured.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • CSC (over 3 months) when subretinal fluid persisted in the subfoveal region demonstrated by clinical examination and OCT
  • Ability to maintain steady fixation for mfERG
  • Presence of abnormal dilated choroidal vasculature in ICGA
  • Symptom duration over 3 months

Exclusion criteria

  • Previous PDT or laser treatment history
  • Evidence of CNV in FAG
  • Other chorioretinal disorders that can cause macular exudation such as age-related macular degeneration, pathologic myopia, angioid streaks, trauma, inflammatory diseases, retinal vasculopathies, and hereditary dystrophies

Treatment and study plan

Primary outcomes

  1. Multifocal Electroretinogram Amplitudes

    Time frame: baseline, 1 month, 3 months, 6 months

    Amplitude at first annular ring at multifocal electroretinogram RETIscan (Roland Consult, Wiesbaden, Germany) is used for multifocal retinogram.

    The recording protocol was chosen according to the International Society for Clinical Electro-physiology of Vision (ISCEV) guidelines.

Secondary outcomes

  1. Best Corrected Visual Acuity

    Time frame: baseline, 1 month, 3 months, 6 months

    Best-corrected visual acuities were obtained with Snellen charts. Snellen's visual acuity was converted logarithm of the minimum angle of resolution (logMAR) for statistical analysis.

Sponsors and collaborators

Lead sponsor

Samsung Medical Center

Other

Registry information

Official study title

Comparison of Multifocal Electroretinogram Assessment Between Laser Treatment Group and Photodynamic Therapy Group in Chronic Central Serous Chorioretinopathy

Important dates

Study start
2008
Primary completion
2008
Study completion
2008
First posted
Dec 5, 2008
Registry last updated
Mar 12, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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