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OpenTrials
Completed

NCT Number: NCT04486248

Comparison of Magnetic Resonance Techniques for the Measurement of Cerebral Blood Perfusion

In this project, we aim at implementing a te-ASL sequence and to compare it to two reference ASL sequences with a fixed PLD on healthy individuals. On the one hand, the te-ASL sequence will be compared against a 3D pCASL with a PLD of 1800 ms, as the current reference according the Consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia. On the other, as the implemented te-ASL sequence will have a 2D readout, it will also be compared to a 2D pCASL ASL sequence with the same PLD, in order to be able to disentangle differences due to the dynamic PLD scheme from those arising from the different read-out schemes.

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Key information

Conditions

Healthy

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

BarcelonaBeta Brain Research Center

Barcelona, 08005, Spain

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • To sign the study informed consent form approved by the corresponding authorities.
  • Healthy men and women (older than 18 years old).

Exclusion criteria

  • Inability or unwillingness to give written informed consent or communicate with the study staff or illiteracy.
  • Any contraindication to perform brain MRI procedure (e.g. pacemaker, MRI-incompatible aneurysm clips).

Treatment and study plan

Primary outcomes

  1. ASL perfusion MRI data

    Time frame: Through study completion, an average of 1 year

    Quantification of cerebral blood flow

Sponsors and collaborators

Lead sponsor

Barcelonabeta Brain Research Center, Pasqual Maragall Foundation

Other

Registry information

Important dates

Study start
2019
Primary completion
2020
Study completion
2022
First posted
Jul 24, 2020
Registry last updated
Mar 31, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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