Skip to main content
OpenTrials
Completed

NCT Number: NCT05517551

Comparison of Low and Normal Flow Anesthesia in Robotic Assisted Radical Prostatectomy

Robot-assisted laparoscopic radical prostatectomy has gained increasing popularity compared to open radical prostatectomy with its advantages such as low blood loss, reduced blood transfusion rate, low complication rate, and shortened hospital stay. Since robot-assisted laparoscopic radical prostatectomy should be performed in the limited retroperitoneal area, insufflation of the abdomen with carbon dioxide (CO2) (pneumoperitoneum) and steep Trendelenburg position are required to provide better surgical vision.

Low-flow anesthesia warms and moistens the inhaled gases, creating a more physiological breathing atmosphere during anesthesia. In addition, it provides cost advantage by reducing inhalation agent consumption and reduces atmospheric pollution. Studies show that long-term minimal flow anesthesia is safe and advantageous for non-laparoscopic surgery.

The aim of this study is to compare low-flow (1L/min) with normal flow (3lt/min) desflurane anesthesia in terms of hemodynamic and respiratory parameters, inhalation agent consumption and soda lime consumption for robotic assisted laparoscopic radical prostatectomy surgery.

The secondary aim of the study is to compare the effects of low-flow and normal-flow anesthesia in the steep trendelenburg position (45°) used for robotically assisted laparoscopic radical prostatectomy.

Completed

Looking for future studies?

Notify Me

Key information

Age range

18 year–80 year

Sex eligibility

Male

Study type

Observational

Primary location

Ankara City Hospital

Ankara, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ASA I-II-III risk group

Exclusion criteria

  • ASA IV, V,
  • concomitant serious cardiac, respiratory, hepatic, renal disturbance,
  • mental status disorder and hearing problem,
  • anxiety and depression and/or other psychiatric disorders,
  • patient's refusal

Treatment and study plan

robotic assisted radical prostatectomy

Procedure

Patients who will undergo robotic-assisted laparoscopic prostatectomy surgery

Primary outcomes

  1. inspiratory O₂ concentration

    Time frame: from beginning of anesthesia induction to the end of anesthesia (during periopertaive period)

    inspiratory O₂ concentration is measured from anesthesia machine monitor

  2. partial oxygen pressure

    Time frame: from beginning of anesthesia induction to the end of anesthesia (during periopertaive period)

    PO2 from blood gas analysis

Secondary outcomes

  1. desflurane consumption

    Time frame: perioperative

    desflurane consumption at the end of anesthesia is measured from anesthesia machine monitor

  2. changes in liver and kidney function tests from the preoperative values to 48 hours postoperative

    Time frame: during operation and 48 hours postoperative

    to determine the changes in serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen (BUN), and creatinine from the preoperative values to 48 hours postoperative

Sponsors and collaborators

Lead sponsor

Ankara City Hospital Bilkent

Other

Registry information

Official study title

The Effect of Low-flow and Normal-flow Desflurane Anesthesia on Respiratory Parameters in Robotic-assisted Radical Prostatectomy

Important dates

Study start
2022
Primary completion
2022
Study completion
2023
First posted
Aug 26, 2022
Registry last updated
May 28, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.