Comparison of Longer-term (5 Year+) Outcomes (Survival) of Smokers, Ex-smokers, Never Smoker and Quitters

Between 2010-2020, the LungCAst observational study followed 3700 patients newly diagnosed with lung cancer across 33 hospitals in Wales and England for 2 years to see if smoking status at time of diagnosis predicted survival rate. This research was sponsored and led by Hywel Dda University Health Board (HDUHB).

This new study examines the health records, (of only the HDUHB participants included in the original LungCAst study), over a longer period of time to see if the benefits of stopping smoking at point of diagnosis with lung cancer continues over a longer period of time (5 years+).

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Key information

Conditions

Lung Cancer - Non Small Cell Squamous Behavior Health Behavior Lung Diseases Lung Neoplasms Neoplasms Neoplasms by Site Respiratory Tract Diseases Respiratory Tract Neoplasms Smoking Cessation Thoracic Neoplasms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Hywel Dda University Health Board

Carmarthen, Carmarthenshire, SA31 3BB, United Kingdom

About this study

A study into longer-term outcomes from the LUNGCAST study: comparing survival and healthcare utilisation according to smoking status in people with lung cancer, beyond 2 years. By obtaining Hospital Episode Statistics (HES) extract from the Welsh Patient Administration System (WPAS) and Welsh Clinical Portal (WCP) the investigators can retrospectively follow the cohort participants over time and analyse health care utilisation activity, using univariate and multivariate analysis on the effect of smoking status on survival. The Kaplan-Meier method, will be used to estimate the probability of survival over time.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

All patients from the Hywel Dda University Health Board's(HDUHB) site that participated in the original LungCast study

Exclusion criteria

Individuals that did not participate in the original LungCast study in the HDUHB site.

Treatment and study plan

Primary outcomes

Comparison of longer-term (5 year+) outcomes (survival) of smokers, ex-smokers and never smokers diagnosed with lung cancer between 2010 and 2020

Time frame: From date of diagnosis (of having lung cancer) for 5 years

Following participants with lung cancer over a 5 year period, by reviewing ongoing healthcare activity via HES extraction and applying the Kaplan-Meier method, to evaluate if smoking status at diagnosis predicts better survival rates over a longer period of time. Univariate and multivariate analysis on the effect of smoking status on survival will also be applied.

Sponsors and collaborators

Lead sponsor

Hywel Dda Health Board

Other

Registry information

Official study title

Comparison of Longer Term Outcomes Following the LungCast "Smoking Cessation in Lung Cancer Study". Revisiting the Original LungCast Research Cohort to Look at Longer-term Outcomes (5+ Years) in Newly Diagnosed Lung Cancer, Within Hywel Dda University Health Board Participants Only, Who Were Smokers, Ex-smokers, Never Smoker and Quitters.

Acronym: LungCast2

Important dates

Study start: 2024
Primary completion: 2025
Study completion: 2025
First posted: Aug 17, 2025
Registry last updated: Aug 17, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed