Skip to main content
OpenTrials
Completed

NCT Number: NCT07725159

Comparison of Lee-Huang Point and Umbilical Entry for Laparoscopic Success in Endometrial Cancer Patients

This randomized controlled trial compares Lee-Huang point entry with conventional umbilical entry for laparoscopic surgery in patients with endometrial cancer. The study aims to evaluate the success of abdominal entry, entry-related complications, operative outcomes, and perioperative safety. A total of 202 patients were randomized to either the Lee-Huang entry group or the umbilical entry group and underwent laparoscopic surgical staging. The findings are expected to provide evidence regarding the optimal primary entry technique for laparoscopic management of endometrial cancer.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Endometrial Cancer Endometrial Neoplasms Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Genital Diseases Genital Diseases, Female Genital Neoplasms, Female Neoplasms Neoplasms by Site Urogenital Diseases Urogenital Neoplasms Uterine Diseases Uterine Neoplasms

Age range

18 year and older

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

University of Health Sciences Turkey, Kartal Dr. Lütfi Kırdar City Hospital

Istanbul, 34865, Turkey (Türkiye)

About this study

This single-center prospective randomized controlled trial was conducted at the Department of Gynecologic Oncology, Kartal Dr. Lutfi Kirdar City Hospital, University of Health Sciences Turkey. Eligible patients with endometrial cancer scheduled for laparoscopic surgical staging were randomly assigned to either Lee-Huang point entry or conventional umbilical entry. The primary objective was to compare successful abdominal access and entry-related complications between the two techniques. Secondary outcomes included operative time, blood loss, conversion to laparotomy, intraoperative and postoperative complications, and other perioperative outcomes. A total of 202 patients completed the study.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Female patients aged 18 years or older.
  • Scheduled for elective laparoscopic gynecologic surgery.
  • Eligible for laparoscopic abdominal entry through either the Lee-Huang point or the umbilical entry site.
  • Provided written informed consent.

Exclusion criteria

  • Pregnancy.
  • Emergency surgery.
  • Previous upper abdominal surgery precluding safe Lee-Huang point or umbilical entry.
  • Contraindication to laparoscopy.
  • Refusal or inability to provide informed consent.

Treatment and study plan

Laparoscopic entry through the Lee-Huang point

Procedure

Initial laparoscopic abdominal entry was performed by direct tracar insertion through the Lee-Huang point

Standart umbilical laparoscopic entry

Procedure

Initial laparoscopic abdominal entry was performed by direct trocar insertion through the umbilicus.

Primary outcomes

  1. Successful laparoscopic abdominal entry

    Time frame: During surgery

    Successful intraperitoneal access through the assigned entry site using direct trocar insertion without the need for conversion to another abdominal entry technique.

Secondary outcomes

  1. Entry-related complications

    Time frame: During surgery

    Incidence of bowel injury, vascular injury, and other complications related to direct trocar insertion through the assigned entry site.

Sponsors and collaborators

Lead sponsor

Dr. Lutfi Kirdar Kartal Training and Research Hospital

Other Gov

Registry information

Official study title

Comparison of Lee-Huang Point and Umbilical Entry for Laparoscopic Surgery in Endometrial Cancer Patients: A Prospective Randomized Controlled Trial

Acronym: LEAP

Important dates

Study start
2024
Primary completion
2026
Study completion
2026
First posted
Jul 24, 2026
Registry last updated
Jul 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.