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NCT Number: NCT06759454

Comparison of LASER Therapy and Desensitizing Agents in Dentinal Hypersensitivity

This study evaluates the effectiveness of laser therapy versus desensitizing agents in reducing pain among participants with dentinal hypersensitivity conducted in Saidu College of Dentistry. Pain will be measured at baseline, immediately post-treatment, one week, and three months using the Visual Analog Scale (VAS)

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Key information

Conditions

Dentinal Hypersensitivity

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Saidu College of Dentistry

Swat, KPK, Pakistan

Location contact

BREKHNA YOUSAFZAI

PRINCIPAL_INVESTIGATOR

FAYYAZ ALAM

SUB_INVESTIGATOR

KEMIA GUL

SUB_INVESTIGATOR

Saidu College of Dentistry Saidu Sharif Swat

CONTACT

[email protected]

009469240142

About this study

This study examines dentinal hypersensitivity treatment modalities, including laser therapy and desensitizing agents. The study is conducted in compliance with regional ethical guidelines

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Participants aged 18-50 years with a preoperative VAS score of ≥2 for dentinal hypersensitivity.
  • Participants with sensitivity due to gingival recession, cervical abrasion, or enamel erosion.
  • Participants with good systemic health.
  • Minimum of two hypersensitive teeth present in two different quadrants.

Exclusion criteria

  • Teeth with caries, defective restorations, or cervical defects > 2 mm (may affect sensitivity measurements).
  • Periodontal surgery or deep periodontal pockets (> 6 mm) within the past three months (potential influence on periodontal health and sensitivity).
  • Participants using desensitizing toothpaste within the past three months (could interfere with study outcomes).
  • Presence of gross oral pathology or systemic diseases (e.g., eating disorders, chronic diseases, uncontrolled metabolic conditions) (may alter oral health status).
  • Pregnant or lactating women (hormonal changes can influence oral health).

Treatment and study plan

Glutaraldehyde-Based Desensetizing Agent

Drug

A glutaraldehyde-based desensitizing agent applied to the cervical area of affected teeth using a micro-brush, left undisturbed for 30 seconds, and air-dried. Both interventions aim to reduce pain associated with dentinal hypersensitivity by either occluding dentinal tubules or reducing nerve excitability

Low Level Laser Therapy

Device

Low-level laser therapy (LLLT) using a diode laser set to a low power level (e.g., 100 mW, continuous wave mode). Each affected tooth will be treated for three minutes, targeting apical, cervical, and middle points

Primary outcomes

  1. Change in pain intensity: Visual Analog Scale

    Time frame: Immediately post-treatment, one week, and three months

    After intervention there is a possibility of change in pain intensity in Dentinal Hypersensitivity

Study contacts

Contact information is provided by the study sponsor or research team.

Brekhna Yousafzai

CONTACT

[email protected]

+923417262127

Kemia Gul

CONTACT

[email protected]

+923352803890

Sponsors and collaborators

Lead sponsor

Kemia Gul

Other

Registry information

Official study title

Comparison of Mean Pain Score Using LASER Therapy and Desensitizing Agents in Patients With Dentinal Hypersensitivity: A Randomized Controlled Trial

Important dates

Study start
2025
Primary completion
2025
Study completion
2026
First posted
Jan 6, 2025
Registry last updated
May 11, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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