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NCT Number: NCT07036445

Comparison of Interlaminar CT Guided Epidural Platelet Rich Plasma Versus Steroid Injection in Patients With Lumbar Radicular Pain

The treatment of persistent lumbar radicular pain (LRP) using CT-guided epidural steroid injection (ESI) is widely used and associated with rare but serious complications. Platelet-rich plasma (PRP), which has recently been shown to promote healing and the anti-inflammatory process by delivering growth factors and cytokines, could be an alternative and potentially safer option. A previous study showed that PRP was as effective as ESI in treating this condition, without major complications.

This study aims to compare these two treatments over the long term (2 years).

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Key information

Conditions

Herniated Disc Bone Diseases Hernia Intervertebral Disc Displacement Musculoskeletal Diseases Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Spinal Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosis of unilateral resistant LRP associated with a herniated disc on MRI images. (Diagnosis of resistance after 6 weeks of appropriate medical treatment).

Exclusion criteria

  • Patients with infections,
  • Patients who have had previous percutaneous corticosteroid injections,
  • Patients undergoing systemic corticosteroid treatment,
  • Patients with immune deficiencies,
  • Patients who are allergic to the contrast medium used,
  • Pregnant or breastfeeding patients,
  • Patients with a history of allergies to anesthetics or corticosteroids,
  • Anticoagulant treatment or blood disorders, patients on antiplatelet therapy
  • Taking NSAIDs within two weeks prior to the procedure

Treatment and study plan

epidural steroid injection

Procedure

Intervention consists of interlaminar CT guided epidural steroid injection

Epidural platelet-rich plasma injection

Procedure

Intervention consists of interlaminar CT guided epidural platelet-rich plasma injection after recovery of plasma by blood sampling and centrifugation

Primary outcomes

  1. Functional ability

    Time frame: 30 minutes before procedure ; 6 weeks after procedure ; 6 months, 1 year, 2 years after procedure

    Oswestry Disability Questionnaire ranging from 0 to 100%

Secondary outcomes

  1. Pain evaluation

    Time frame: 6 weeks, 6 months, 1 year and 2 years after procedure

    Numerical pain rating scale (NRS): intensity of combined pain in the legs and back ranging from 0 to 10

Sponsors and collaborators

Lead sponsor

Clinique du Sport, Bordeaux Mérignac

Other

Registry information

Official study title

Comparison of Interlaminar CT Guided Epidural Platelet Rich Plasma Versus Steroid Injection in Patients With Lumbar Radicular Pain : a Prospective Study With Long Term Follow up

Important dates

Study start
2025
Primary completion
2028
Study completion
2028
First posted
Jun 25, 2025
Registry last updated
Sep 18, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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