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OpenTrials
Completed

NCT Number: NCT02976311

Comparison of Inflammatory Responses Subsequent to Different Cesarean Section Techniques

In this study, the investigators aimed to find out whether there are any differences in inflammatory reactions occured subsequent to two different cesarean delivery techniques; modified Misgav-Ladach vs Pfannenstiel-Kerr techniques.

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Key information

Age range

18 year–35 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

About this study

Cesarean section is one of the most undertaken operations in women of childbearing age. However, there is not a unique cesarean surgery technique. Pfannenstiel , reported his own technique in 1897. Because of the applicability of the technique, it went down well among obstetricians. After three decades, Kerr evolved this technique, and Pfannenstiel-Kerr technique became the method of choice until late 70's. In 1972, Stark et al defined the Misgav Ladach technique and in the following years this technique became popular among obstetricians. In late 80's Misgav Ladach technique was modified and started to be more popular. But, still Pfannenstiel-Kerr technique continued to be used frequently and studies comparing clinical outcomes of these two techniques were conducted for several times. However, the inflammatory responses which occured subsequent to application of these techniques were not investigated. This is the first study investigating the inflammatory response emerged after different cesarean surgery techniques.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Cesarean section for the first time
  • Term,singleton pregnancy

Exclusion criteria

  • Any inflammatory disease
  • Any pregnancy complication; IUGR,preeclampsia,preterm labor,preterm premature rupture of membranes
  • Pregnancies <37weeks gestational age

Treatment and study plan

cesarean section(C/S) via the modified Misgav-Ladach technique

Procedure

the first consecutive 44 patients underwent C/S via the modified Misgav-Ladach technique

cesarean section via the Pfannenstiel-Kerr technique

Procedure

the second consecutive 44 patients underwent C/S via the Pfannenstiel-Kerr technique

Primary outcomes

  1. IL-6

    Time frame: 24 hours

    percentage of difference in serum IL-6 levels just before the beginning of the surgery and at the 24th hour of the surgery

  2. TNF-alpha

    Time frame: 24 hours

    percentage of difference in serum IL-6 levels just before the beginning of the surgery and at the 24th hour of the surgery

Sponsors and collaborators

Lead sponsor

Kayseri Education and Research Hospital

Other Gov

Registry information

Official study title

Comparison of Inflammatory Reactions Following Two Different Cesarean Surgery Techniques; The Modified Misgav-Ladach Versus the Pfannenstiel-Kerr Technique

Acronym: C/S

Important dates

Study start
2016
Primary completion
2016
Study completion
2016
First posted
Nov 29, 2016
Registry last updated
Nov 29, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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