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OpenTrials
Completed

NCT Number: NCT02912520

Comparison of IgA Levels in the Bronchoalveolar Lavage Fluid of Patients With and Without Antibiotic Therapy

Investigators hypothesize that Immunoglobine (Ig) production is influenced by the microbiota of the gut. Investigators will compare microbiota-dependent Ig production in the bronchoalveolar lavage fluid of patients with and without antibiotic therapy in order to detect significant differences.

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Key information

Conditions

Immunoglobulin A

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Medical University of Vienna

Vienna, 1090, Austria

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • endotracheal intubation
  • antibiotic therapy for 2 weeks OR no antibiotic therapy for at least 3 months

Exclusion criteria

  • active infection
  • pregnancy
  • immunodeficiency

Treatment and study plan

Anti-Bacterial Agents

Drug

administration of any antibiotic substance(s) over the course of 2 weeks

Primary outcomes

  1. IgA levels in the bronchoalveolar lavage fluid

    Time frame: 2 weeks of ICU stay

Secondary outcomes

  1. number of detected bacterial, viral, and fungal infections per patient

    Time frame: through study completion, an average of 2 months

Sponsors and collaborators

Lead sponsor

Medical University of Vienna

Other

Registry information

Important dates

Study start
2016
Primary completion
2017
Study completion
2017
First posted
Sep 23, 2016
Registry last updated
Apr 25, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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