Comparison of Hyperemic Efficacy Between Central and Peripheral Adenosine Infusion for Fractional Flow Reserve (FFR) Measurement

The purpose of this study is to evaluate the safety and effectiveness of the peripheral IV continuous infusion without the insertion of central venous vascular access method in the achievement of steady-state maximal coronary hyperemia compared with the central IV continuous infusion method.

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Key information

Conditions

Coronary Artery Disease Arterial Occlusive Diseases Arteriosclerosis Cardiovascular Diseases Coronary Disease Heart Diseases Hyperemia Myocardial Ischemia Vascular Diseases

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Cardiovascular Center, Seoul National University Hospital

Seoul, South Korea

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

non -infarct related, patients with moderate coronary artery stenosis
normal ejection fraction on echocardiogram

Exclusion criteria

infarct-related arteries or clinically unstable state
collateral blood flow to the target vessel is shown
atrioventricular block on electrocardiogram
reduced ejection fraction(<50%) or left ventricular hypertrophy on echocardiography
contraindication of adenosine

Treatment and study plan

FFR via central venous line

Other

Patients with intermediate coronary artery stenosis were consecutively enrolled. FFR was measured by a standard intravenous (IV) adenosine infusion (140 μg•min-1•kg-1) via Rt central femoral vein.

FFR via peripheral venous line

Other

Primary outcomes

compare fractional flow reserve at maximal hyperemia

Time frame: interval of 10 minutes

Secondary outcomes

compare the time to maximal hyperemia and changes in heart rate

Time frame: interval of 10 minutes

Sponsors and collaborators

Lead sponsor

Seoul National University Hospital

Other

Registry information

Important dates

Study start: 2009
Primary completion: 2011
Study completion: 2011
First posted: Feb 18, 2010
Registry last updated: Jul 18, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed