Completed

NCT Number: NCT05466604

Comparison of Hyaluronidase and Dexametasone in Reduction of Postoperative Edema

The present study is designed to reveal effectiveness of hyaluronidase and dexamethasone on reduction of postoperative edema, pain, trismus, and infection. For this purpose, 60 participants with symmetrical mandibular wisdom teeth enrolled the present study. All measurements and evaluations were performed before and 1, 2, 3, and 7 days later the operation.

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Key information

Conditions

Edema Agnosia Infection, Surgical Site Infections Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Neuromuscular Manifestations Pain Pathologic Processes Pathological Conditions, Signs and Symptoms Perceptual Disorders Postoperative Complications Signs and Symptoms Spasm Surgical Wound Infection Trismus Wound Infection

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Near East University, Nicosia, Cyprus

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

symmetrical mandibular wisdom teeth with bone retention
patients who are signed informed consent and acceptance of study involvement forms

Exclusion criteria

existence of any systemic disease
existence of any periodical drug intake
existence of difference in operation times of right and left impacted wisdom teeth extractions more than 5 minutes
existence of pregnancy
existence of breastfeeding

Treatment and study plan

Hyaluronidase Injection mesomedica

Drug

injection of 150 IU hyaluronidase to perioperative region, submucosally.

Dexamethasone dekort

Drug

injection of 8 mg dexamethasone to perioperative region, submucosally.

Primary outcomes

evaluation of the increase of edema in postoperative 1. day using a measuring tape in hyaluronidase experimental group

Time frame: postoperative 1. day

preoperative edema amount was subtracted from edema amount in 1. day in hyaluronidase experimental group
evaluation of the increase of edema in postoperative 2. day using a measuring tape in hyaluronidase experimental group

Time frame: postoperative 2. day

preoperative edema amount was subtracted from edema amount in 2. day in hyaluronidase experimental group
evaluation of the increase of edema in postoperative 3. day using a measuring tape in hyaluronidase experimental group

Time frame: postoperative 3. day

preoperative edema amount was subtracted from edema amount in 3. day in hyaluronidase experimental group
evaluation of the increase of edema in postoperative 7. day using a measuring tape in hyaluronidase experimental group

Time frame: postoperative 7. day

preoperative edema amount was subtracted from edema amount in 7. day in hyaluronidase experimental group
evaluation of the increase of edema in postoperative 1. day using a measuring tape in hyaluronidase control group

Time frame: postoperative 1. day

preoperative edema amount was subtracted from edema amount in 1. day in hyaluronidase control group
evaluation of the increase of edema in postoperative 2. day using a measuring tape in hyaluronidase control group

Time frame: postoperative 2. day

preoperative edema amount was subtracted from edema amount in 2. day in hyaluronidase control group
evaluation of the increase of edema in postoperative 3. day using a measuring tape in hyaluronidase control group

Time frame: postoperative 3. day

preoperative edema amount was subtracted from edema amount in 3. day in hyaluronidase control group
evaluation of the increase of edema in postoperative 7. day using a measuring tape in hyaluronidase control group

Time frame: postoperative 7. day

preoperative edema amount was subtracted from edema amount in 7. day in hyaluronidase control group
evaluation of the increase of edema in postoperative 1. day using a measuring tape in dexamethasone experimental group

Time frame: postoperative 1. day

preoperative edema amount was subtracted from edema amount in 1. day in dexamethasone experimental group
evaluation of the increase of edema in postoperative 2. day using a measuring tape in dexamethasone experimental group

Time frame: postoperative 2. day

preoperative edema amount was subtracted from edema amount in 2. day in dexamethasone experimental group
evaluation of the increase of edema in postoperative 3. day using a measuring tape in dexamethasone experimental group

Time frame: postoperative 3. day

preoperative edema amount was subtracted from edema amount in 3. day in dexamethasone experimental group
evaluation of the increase of edema in postoperative 7. day using a measuring tape in dexamethasone experimental group

Time frame: postoperative 7. day

preoperative edema amount was subtracted from edema amount in 7. day in dexamethasone experimental group
evaluation of the increase of edema in postoperative 1. day using a measuring tape in dexamethasone control group

Time frame: postoperative 1. day

preoperative edema amount was subtracted from edema amount in 1. day in dexamethasone controlgroup
evaluation of the increase of edema in postoperative 2. day using a measuring tape in dexamethasone control group

Time frame: postoperative 2. day

preoperative edema amount was subtracted from edema amount in 2. day in dexamethasone controlgroup
evaluation of the increase of edema in postoperative 3. day using a measuring tape in dexamethasone control group

Time frame: postoperative 3. day

preoperative edema amount was subtracted from edema amount in 3. day in dexamethasone controlgroup
evaluation of the increase of edema in postoperative 7. day using a measuring tape in dexamethasone control group

Time frame: postoperative 7. day

preoperative edema amount was subtracted from edema amount in 7. day in dexamethasone controlgroup
evaluation of the difference in increase amounts of edema between hyaluronidase experimental and hyaluronidase control groups in postoperative 1. day using a measuring tape

Time frame: postoperative 1. day

edema increase amount of hyaluronidase experimental group was compared with that of hyaluronidase control group in postoperative 1. day
evaluation of the difference in increase amounts of edema between hyaluronidase experimental and hyaluronidase control groups in postoperative 2. day using a measuring tape

Time frame: postoperative 2. day

edema increase amount of hyaluronidase experimental group was compared with that of hyaluronidase control group in postoperative 2. day
evaluation of the difference in increase amounts of edema between hyaluronidase experimental and hyaluronidase control groups in postoperative 3. day using a measuring tape

Time frame: postoperative 3. day

edema increase amount of hyaluronidase experimental group was compared with that of hyaluronidase control group in postoperative 3. day
evaluation of the difference in increase amounts of edema between hyaluronidase experimental and hyaluronidase control groups in postoperative 7. day using a measuring tape

Time frame: postoperative 7. day

edema increase amount of hyaluronidase experimental group was compared with that of hyaluronidase control group in postoperative 7. day
evaluation of the difference in increase amounts of edema between dexamethasone experimental and dexamethasone control groups in postoperative 1. day using a measuring tape

Time frame: postoperative 1. day

edema increase amount of dexamethasone experimental group was compared with that of dexamethasone control group in postoperative 1. day
evaluation of the difference in increase amounts of edema between dexamethasone experimental and dexamethasone control groups in postoperative 2. day using a measuring tape

Time frame: postoperative 2. day

edema increase amount of dexamethasone experimental group was compared with that of dexamethasone control group in postoperative 2. day
evaluation of the difference in increase amounts of edema between dexamethasone experimental and dexamethasone control groups in postoperative 3. day using a measuring tape

Time frame: postoperative 3. day

edema increase amount of dexamethasone experimental group was compared with that of dexamethasone control group in postoperative 3. day
evaluation of the difference in increase amounts of edema between dexamethasone experimental and dexamethasone control groups in postoperative 7. day using a measuring tape

Time frame: postoperative 7. day

edema increase amount of dexamethasone experimental group was compared with that of dexamethasone control group in postoperative 7. day
evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase experimental group in postoperative 1. day

Time frame: postoperative 1. day

pain intensity of the patients in hyaluronidase experimental group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 1. day
evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase experimental group in postoperative 2. day

Time frame: postoperative 2. day

pain intensity of the patients in hyaluronidase experimental group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 2. day
evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase experimental group in postoperative 3. day

Time frame: postoperative 3. day

pain intensity of the patients in hyaluronidase experimental group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 3. day
evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase experimental group in postoperative 4. day

Time frame: postoperative 4. day

pain intensity of the patients in hyaluronidase experimental group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 4. day
evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase experimental group in postoperative 5. day

Time frame: postoperative 5. day

pain intensity of the patients in hyaluronidase experimental group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 5. day
evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase experimental group in postoperative 6. day

Time frame: postoperative 6. day

pain intensity of the patients in hyaluronidase experimental group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 6. day
evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase experimental group in postoperative 7. day

Time frame: postoperative 7. day

pain intensity of the patients in hyaluronidase experimental group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 7. day
evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase control group in postoperative 1. day

Time frame: postoperative 1. day

pain intensity of the patients in hyaluronidase control group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 1. day
evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase control group in postoperative 2. day

Time frame: postoperative 2. day

pain intensity of the patients in hyaluronidase control group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 2. day
evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase control group in postoperative 3. day

Time frame: postoperative 3. day

pain intensity of the patients in hyaluronidase control group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 3. day
evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase control group in postoperative 4. day

Time frame: postoperative 4. day

pain intensity of the patients in hyaluronidase control group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 4. day
evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase control group in postoperative 5. day

Time frame: postoperative 5. day

pain intensity of the patients in hyaluronidase control group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 5. day
evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase control group in postoperative 6. day

Time frame: postoperative 6. day

pain intensity of the patients in hyaluronidase control group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 6. day
evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase control group in postoperative 7. day

Time frame: postoperative 7. day

pain intensity of the patients in hyaluronidase control group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 7. day
evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone experimental group in postoperative 1. day

Time frame: postoperative 1. day

pain intensity of the patients in dexamethasone experimental group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 1. day
evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone experimental group in postoperative 2. day

Time frame: postoperative 2. day

pain intensity of the patients in dexamethasone experimental group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 2. day
evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone experimental group in postoperative 3. day

Time frame: postoperative 3. day

pain intensity of the patients in dexamethasone experimental group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 3. day
evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone experimental group in postoperative 4. day

Time frame: postoperative 4. day

pain intensity of the patients in dexamethasone experimental group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 4. day
evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone experimental group in postoperative 5. day

Time frame: postoperative 5. day

pain intensity of the patients in dexamethasone experimental group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 5. day
evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone experimental group in postoperative 6. day

Time frame: postoperative 6. day

pain intensity of the patients in dexamethasone experimental group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 6. day
evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone experimental group in postoperative 7. day

Time frame: postoperative 7. day

pain intensity of the patients in dexamethasone experimental group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 7. day
evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone control group in postoperative 1. day

Time frame: postoperative 1. day

pain intensity of the patients in dexamethasone control group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 1. day
evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone control group in postoperative 2. day

Time frame: postoperative 2. day

pain intensity of the patients in dexamethasone control group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 2. day
evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone control group in postoperative 3. day

Time frame: postoperative 3. day

pain intensity of the patients in dexamethasone control group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 3. day
evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone control group in postoperative 4. day

Time frame: postoperative 4. day

pain intensity of the patients in dexamethasone control group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 4. day
evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone control group in postoperative 5. day

Time frame: postoperative 5. day

pain intensity of the patients in dexamethasone control group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 5. day
evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone control group in postoperative 6. day

Time frame: postoperative 6. day

pain intensity of the patients in dexamethasone control group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 6. day
evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone control group in postoperative 7. day

Time frame: postoperative 7. day

pain intensity of the patients in dexamethasone control group was assessed using visual analog scale (VAS) and daily count of NSAİ drug intake in postoperative 7. day
evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase experimental group preoperatively.

Time frame: preoperative

amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler
evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase experimental group in postoperative 1. day.

Time frame: postoperative 1. day

amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler
evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase experimental group in postoperative 2. day.

Time frame: postoperative 2. day

amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler
evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase experimental group in postoperative 3. day.

Time frame: postoperative 3. day

amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler
evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase experimental group in postoperative 7. day.

Time frame: postoperative 7. day

amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler
evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase control group preoperatively.

Time frame: preoperative

amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler
evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase control group in postoperative 1. day.

Time frame: postoperative 1. day

amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler
evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase control group in postoperative 2. day.

Time frame: postoperative 2. day

amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler
evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase control group in postoperative 3. day.

Time frame: postoperative 3. day

amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler
evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase control group in postoperative 7. day.

Time frame: postoperative 7. day

amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler
evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of dexamethasone experimental group preoperatively.

Time frame: preoperative

amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler
evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of dexamethasone experimental group in postoperative 1. day.

Time frame: postoperative 1. day

amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler
evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of dexamethasone experimental group in postoperative 2. day.

Time frame: postoperative 2. day

amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler
evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of dexamethasone experimental group in postoperative 3. day.

Time frame: postoperative 3. day

amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler
evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of dexamethasone experimental group in postoperative 7. day.

Time frame: postoperative 7. day

amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler
evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of dexamethasone control group preoperatively.

Time frame: preoperative

amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler
evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of dexamethasone control group in postoperative 1. day.

Time frame: postoperative 1. day

amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler
evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of dexamethasone control group in postoperative 2. day.

Time frame: postoperative 2. day

amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler
evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of dexamethasone control group in postoperative 3. day.

Time frame: postoperative 3. day

amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler
evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of dexamethasone control group in postoperative 7. day.

Time frame: postoperative 7. day

amount of trismus is revealed measuring the distance between the tips of incisal edges of mandibular and maxillary right first incisors using a ruler
evaluation of infection in operation site via determination of infection signs in physical examination of hyaluronidase experimental group preoperatively.

Time frame: preoperative

existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.
evaluation of infection in operation site via determination of infection signs in physical examination of hyaluronidase experimental group in postoperative 1. day.

Time frame: postoperative 1. day

existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.
evaluation of infection in operation site via determination of infection signs in physical examination of hyaluronidase experimental group in postoperative 2. day.

Time frame: postoperative 2. day

existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.
evaluation of infection in operation site via determination of infection signs in physical examination of hyaluronidase experimental group in postoperative 3. day.

Time frame: postoperative 3. day

existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.
evaluation of infection in operation site via determination of infection signs in physical examination of hyaluronidase experimental group in postoperative 7. day.

Time frame: postoperative 7. day

existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.
evaluation of infection in operation site via determination of infection signs in physical examination of hyaluronidase control group preoperatively.

Time frame: preoperative

existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.
evaluation of infection in operation site via determination of infection signs in physical examination of hyaluronidase control group in postoperative 1. day.

Time frame: postoperative 1. day

existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.
evaluation of infection in operation site via determination of infection signs in physical examination of hyaluronidase control group in postoperative 2. day.

Time frame: postoperative 2. day

existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.
evaluation of infection in operation site via determination of infection signs in physical examination of hyaluronidase control group in postoperative 3. day.

Time frame: postoperative 3. day

existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.
evaluation of infection in operation site via determination of infection signs in physical examination of hyaluronidase control group in postoperative 7. day.

Time frame: postoperative 7. day

existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.
evaluation of infection in operation site via determination of infection signs in physical examination of dexamethasone experimental group preoperatively.

Time frame: preoperative

existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.
evaluation of infection in operation site via determination of infection signs in physical examination of dexamethasone experimental group in postoperative 1. day

Time frame: postoperative 1. day

existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.
evaluation of infection in operation site via determination of infection signs in physical examination of dexamethasone experimental group in postoperative 2. day

Time frame: postoperative 2. day

existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.
evaluation of infection in operation site via determination of infection signs in physical examination of dexamethasone experimental group in postoperative 3. day

Time frame: postoperative 3. day

existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.
evaluation of infection in operation site via determination of infection signs in physical examination of dexamethasone experimental group in postoperative 7. day

Time frame: postoperative 7. day

existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.
evaluation of infection in operation site via determination of infection signs in physical examination of dexamethasone control group preoperatively.

Time frame: preoperatively

existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.
evaluation of infection in operation site via determination of infection signs in physical examination of dexamethasone control group in postoperative 1. day

Time frame: postoperative 1. day

existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.
evaluation of infection in operation site via determination of infection signs in physical examination of dexamethasone control group in postoperative 2. day

Time frame: postoperative 2. day

existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.
evaluation of infection in operation site via determination of infection signs in physical examination of dexamethasone control group in postoperative 3. day

Time frame: postoperative 3. day

existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.
evaluation of infection in operation site via determination of infection signs in physical examination of dexamethasone control group in postoperative 7. day

Time frame: postoperative 7. day

existence of infection signs were determined using physical examination method. if the count of + signs are more than half of total amount of determined signs, the evaluation is accepted as (+) infected.

Sponsors and collaborators

Lead sponsor

Hacettepe University

Other

Registry information

Official study title

Comparison of the Effects of Hyaluronidase and Dexamethasone on Reduction of Postoperative Edema in Impacted Wisdom Teeth Surgery

Important dates

Study start: 2019
Primary completion: 2022
Study completion: 2022
First posted: Jul 20, 2022
Registry last updated: Jul 20, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Key information

Conditions

Sex eligibility

Study type

Phase

Primary location

Who can participate

Treatment and study plan

Hyaluronidase Injection mesomedica

Dexamethasone dekort

Primary outcomes

evaluation of the increase of edema in postoperative 1. day using a measuring tape in hyaluronidase experimental group

evaluation of the increase of edema in postoperative 2. day using a measuring tape in hyaluronidase experimental group

evaluation of the increase of edema in postoperative 3. day using a measuring tape in hyaluronidase experimental group

evaluation of the increase of edema in postoperative 7. day using a measuring tape in hyaluronidase experimental group

evaluation of the increase of edema in postoperative 1. day using a measuring tape in hyaluronidase control group

evaluation of the increase of edema in postoperative 2. day using a measuring tape in hyaluronidase control group

evaluation of the increase of edema in postoperative 3. day using a measuring tape in hyaluronidase control group

evaluation of the increase of edema in postoperative 7. day using a measuring tape in hyaluronidase control group

evaluation of the increase of edema in postoperative 1. day using a measuring tape in dexamethasone experimental group

evaluation of the increase of edema in postoperative 2. day using a measuring tape in dexamethasone experimental group

evaluation of the increase of edema in postoperative 3. day using a measuring tape in dexamethasone experimental group

evaluation of the increase of edema in postoperative 7. day using a measuring tape in dexamethasone experimental group

evaluation of the increase of edema in postoperative 1. day using a measuring tape in dexamethasone control group

evaluation of the increase of edema in postoperative 2. day using a measuring tape in dexamethasone control group

evaluation of the increase of edema in postoperative 3. day using a measuring tape in dexamethasone control group

evaluation of the increase of edema in postoperative 7. day using a measuring tape in dexamethasone control group

evaluation of the difference in increase amounts of edema between hyaluronidase experimental and hyaluronidase control groups in postoperative 1. day using a measuring tape

evaluation of the difference in increase amounts of edema between hyaluronidase experimental and hyaluronidase control groups in postoperative 2. day using a measuring tape

evaluation of the difference in increase amounts of edema between hyaluronidase experimental and hyaluronidase control groups in postoperative 3. day using a measuring tape

evaluation of the difference in increase amounts of edema between hyaluronidase experimental and hyaluronidase control groups in postoperative 7. day using a measuring tape

evaluation of the difference in increase amounts of edema between dexamethasone experimental and dexamethasone control groups in postoperative 1. day using a measuring tape

evaluation of the difference in increase amounts of edema between dexamethasone experimental and dexamethasone control groups in postoperative 2. day using a measuring tape

evaluation of the difference in increase amounts of edema between dexamethasone experimental and dexamethasone control groups in postoperative 3. day using a measuring tape

evaluation of the difference in increase amounts of edema between dexamethasone experimental and dexamethasone control groups in postoperative 7. day using a measuring tape

evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase experimental group in postoperative 1. day

evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase experimental group in postoperative 2. day

evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase experimental group in postoperative 3. day

evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase experimental group in postoperative 4. day

evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase experimental group in postoperative 5. day

evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase experimental group in postoperative 6. day

evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase experimental group in postoperative 7. day

evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase control group in postoperative 1. day

evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase control group in postoperative 2. day

evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase control group in postoperative 3. day

evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase control group in postoperative 4. day

evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase control group in postoperative 5. day

evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase control group in postoperative 6. day

evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in hyaluronidase control group in postoperative 7. day

evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone experimental group in postoperative 1. day

evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone experimental group in postoperative 2. day

evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone experimental group in postoperative 3. day

evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone experimental group in postoperative 4. day

evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone experimental group in postoperative 5. day

evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone experimental group in postoperative 6. day

evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone experimental group in postoperative 7. day

evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone control group in postoperative 1. day

evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone control group in postoperative 2. day

evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone control group in postoperative 3. day

evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone control group in postoperative 4. day

evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone control group in postoperative 5. day

evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone control group in postoperative 6. day

evaluation of the pain using visual analog scale (VAS) and daily count of NSAİ drug intake in dexamethasone control group in postoperative 7. day

evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase experimental group preoperatively.

evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase experimental group in postoperative 1. day.

evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase experimental group in postoperative 2. day.

evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase experimental group in postoperative 3. day.

evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase experimental group in postoperative 7. day.

evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase control group preoperatively.

evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase control group in postoperative 1. day.

evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase control group in postoperative 2. day.

evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase control group in postoperative 3. day.

evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of hyaluronidase control group in postoperative 7. day.

evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of dexamethasone experimental group preoperatively.

evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of dexamethasone experimental group in postoperative 1. day.

evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of dexamethasone experimental group in postoperative 2. day.

evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of dexamethasone experimental group in postoperative 3. day.

evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of dexamethasone experimental group in postoperative 7. day.

evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of dexamethasone control group preoperatively.

evaluation of trismus using a ruler, which measures the opening between mandibular and maxillary right first incisors of dexamethasone control group in postoperative 1. day.