Skip to main content
OpenTrials
Completed

NCT Number: NCT06436105

Comparison of Fasia Iliac Compartment Block and 4in1 Block

Patients who will undergo elective total knee arthroplasty surgery under spinal anesthesia will be included in the study according to the postoperative analgesia method applied: Group Control, Group FICB and Group 4in1. Peripheral nerve block will be performed with 30 ml %0.25 bupivacaine for Group FICB and Group 4 in 1 patients. Peripheral nerve block will not be performed on Group Control patients. Patient-controlled analgesia will be given to all three groups in the postoperative period. PCA is a pain palliation method routinely used in all patients postoperatively. NRS score, PCA tramadol consumption, PCA demand, need for additional analgesia, patient satisfaction, nausea and vomiting will be monitored 24 hours postoperatively. The aim of this study is to compare the perioperative analgesic effectiveness of patients who underwent fascia iliaca compartment block and 4 in 1 block in total knee arthroplasty surgery, with each other and with the control group.

Completed

Looking for future studies?

Notify Me

Key information

Age range

18 year–85 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Anesthesiology and Reanimation, University of Health Sciences, Diskapi Yıldırım Beyazit Training and Research Hospital

Ankara, 06450, Turkey (Türkiye)

About this study

Total knee arthroplasty is a surgical procedure performed mostly on patients with osteoarthritis who have failed traditional conservative treatment. Increasing knee osteoarthritis due to reasons such as life expectancy and body mass index causes this surgical procedure to be performed more frequently. The knee joint which is innervated by the femoral, obturator, sciatic nerves and their branches has a complicated innervation and the pain following total knee arthrplasty is quite severe. It is aimed to provide effective analgesia by blocking these nerves or terminal branches with various peripheral nerve blockade methods under USG guidance. In recent years, interest in studies aiming to block these nerves with a single injection has been increasing. 4 in 1 block is a new technique applied from a single injection point to block the saphenous, obturator, sciatic and vastus medialis nerves that innervate the knee joint. Fascia iliaca compartment block is a reliable technique applied from a single injection point to block the femoral, lateral femoral cutaneous and obturator nerves behind the fascia iliaca.

Patients who will undergo elective total knee arthroplasty surgery under spinal anesthesia will be included in the study according to the postoperative analgesia method applied: Group Control, Group FICB and Group 4in1. Peripheral nerve block will be performed with 30 ml %0.25 bupivacaine for Group FICB and Group 4 in 1 patients. Peripheral nerve block will not be performed on Group Control patients. Patient-controlled analgesia will be given to all three groups in the postoperative period. PCA is a pain palliation method routinely used in all patients postoperatively. NRS score, PCA tramadol consumption, PCA demand, need for additional analgesia, patient satisfaction, nausea and vomiting will be monitored 24 hours postoperatively. The aim of this study is to compare the perioperative analgesic effectiveness of patients who underwent fascia iliaca compartment block and 4 in 1 block in total knee arthroplasty surgery, with each other and with the control group.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • With informed consent
  • Elective total knee arthroplasty with spinal anesthesia
  • Oriented and cooperative
  • ASA Classification I-II-III
  • 18-85 years old

Exclusion criteria

  • Anticoagulant medication
  • Coagulopathy
  • Infection at the site of peripheral nerve block application
  • Allergy to local anesthetics
  • Pregnant or suspected pregnancy

Treatment and study plan

FICB

Other

FICB is applied to the patients after spinal anesthesia.

4 in 1 block

Other

4 in 1 block is applied to the patients after spinal anesthesia.

Control

Other

Peripheral nerve block will not be performed on Group Control patients.

Primary outcomes

  1. Total tramadol consumption in 24 hours (mg)

    Time frame: 24 hours postoperatively

    Total tramadol consumption used in the first 24 hours postoperatively

Secondary outcomes

  1. Pain on the Numeric Rating Scale (NRS)

    Time frame: 0 hours postoperatively

    NRS range was from 0-10 with being no pain and 10 the worst pain possible.

  2. Pain on the Numeric Rating Scale (NRS)

    Time frame: 1 hours postoperatively

    NRS range was from 0-10 with being no pain and 10 the worst pain possible.

  3. Pain on the Numeric Rating Scale (NRS)

    Time frame: 4 hours postoperatively

    NRS range was from 0-10 with being no pain and 10 the worst pain possible.

  4. Pain on the Numeric Rating Scale (NRS)

    Time frame: 8 hours postoperatively

    NRS range was from 0-10 with being no pain and 10 the worst pain possible.

  5. Pain on the Numeric Rating Scale (NRS)

    Time frame: 12 hours postoperatively

    NRS range was from 0-10 with being no pain and 10 the worst pain possible.

  6. Pain on the Numeric Rating Scale (NRS)

    Time frame: 24 hours postoperatively

    NRS range was from 0-10 with being no pain and 10 the worst pain possible.

  7. Rescue Analgesic

    Time frame: 24 hours postoperatively

    Consumption of rescue analgesic used after 24 hours postoperatively.

  8. Patient satisfaction

    Time frame: 24 hours postoperatively

    The patient is satisfied or dissatisfied

Sponsors and collaborators

Lead sponsor

Diskapi Yildirim Beyazit Education and Research Hospital

Other Gov

Registry information

Official study title

Comparison of Perioperative Analgesic Effectiveness of Patients Who Had Fasia Iliac Compartment Block and 4in1 Block Applied in Total Knee Prosthesis Surgery

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
May 30, 2024
Registry last updated
Jun 29, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.