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NCT Number: NCT06872528

Comparison of Epidural Analgesia With Intra-Articular Infiltration Analgesia

The results of combining infiltrative analgesia applied by orthopedists with epidural analgesia applied by anesthesiologists after knee replacement surgery will be compared.

It aims to compare epidural analgesia with the maximum reduction of postoperative pain in patients, as well as in terms of both analgesic and complications.

The study will include patients who have undergone knee replacement surgery for six months. In the study, we will compare the results of painkillers applied to the patient from the waist or knee after the waist numbing anesthesia, which includes some of the routinely applied protocols of your knee replacement surgery. It is a condition that will be monitored after surgery. The study aims to reduce maximum pain with two painkiller methods applied in small amounts or together. No interventional application will be made to the patient who will undergo surgery other than routine application. After the surgery, you will be asked verbally about your pain level and side effects at certain hours after the surgery and the amount of painkillers used and the amount of painkillers will be determined according to the follow-up hours (1st, 2nd, 6th, 12th, 24th and 48th hours after the surgery). In addition to these, complications will also be monitored. The results of patients who can be fully followed up at the end of 6 months will be presented as a scientific study.

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Key information

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age range 18-75
  • Those who underwent surgery with combined spinal anesthesia
  • Drugs administered with combined spinal anesthesia and intra-articular infiltration analgesia

Exclusion criteria

  • Those who do not want to participate in the study
  • Those who underwent surgery under general anesthesia
  • Patients outside the specified age range
  • Patients with inadequate follow-up results (patient, drug and device related)

Treatment and study plan

Recording the amount of medication and the number of complications according to observational follow-up

Other

Observational monitoring of patients and recording data for 24 hours

Primary outcomes

  1. Amount of local anesthetic used for epidural analgesia

    Time frame: 6 months

    Is there a statistical difference between the two groups? Monitoring the effect of local infiltration on the amount of epidural analgesic agent

  2. Differences between the two groups in terms of complications and need for additional analgesia

    Time frame: 6 months

    The effect of epidural analgesia and infiltration analgesia on complications and additional analgesia needs in patients

Sponsors and collaborators

Lead sponsor

Namik Kemal University

Other

Registry information

Official study title

Comparison of Epidural Analgesia With Intra-Articular Infiltration Analgesia for Postoperative Total Knee Arthroplasty Analgesia: A Prospective, Randomized Controlled Trial

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Mar 12, 2025
Registry last updated
Mar 12, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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