Comparison of Efficacy Between Piracetam and Dimenhydrinate in Patients With Peripheral Vertigo

This study aims to investigate efficacy of two different intravenous drugs (dimenhydrinate and piracetam) in the symptomatic management of peripheral vertigo.

The patients will be randomized in two groups according to symptomatic treatment modalities: Dimenhydrinate (100 mg) and piracetam (2 g) will be given in 100 cc normal saline in 30 minutes. Each patient will be asked if her/his vertigo symptoms resolved or not, according to a numeric rating scale (0=no vertigo, 10=worst possible vertigo). The patient will be rate the intensity of symptoms in the following times:

* Numeric rating scale (1 to 10): Admission * Numeric rating scale (1 to 10): After the study drug (No ambulation)* * Numeric rating scale (1 to 10): After the study drug (Ambulation)*

* Ambulation refers to head movements or walking in the room, if applicable.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Peripheral Vertigo Ear Diseases Labyrinth Diseases Nervous System Diseases Neurologic Manifestations Otorhinolaryngologic Diseases Pathological Conditions, Signs and Symptoms Signs and Symptoms Vertigo Vestibular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Kocaeli University

Kocaeli, 41000, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Presenting to emergency department with vertigo symptoms
Adult patients (over 18)
Agree to participate to study (understanding the study protocol and signing the informed consent form)

Exclusion criteria

Patients under 18 years
Patients diagnosed with ischemic/hemorrhagic stroke after neuroimaging
Patient diagnosed with transient ischemic attack
Pregnants
Patients taking any analgesics or antihistaminic drugs last 24 hours
Documented or declared allergy to dimenhydrinate, piracetam or benzodiazepines
Patients who do not agree to participate to the study

Treatment and study plan

Administration of 100 mg dimenhydrinate intravenous

Drug

2 g piracetam intravenous

Drug

Primary outcomes

Change in numeric rating scale

Time frame: Change from baseline in numeric rating scale at 30th minute

Sponsors and collaborators

Lead sponsor

Kocaeli University

Other

Registry information

Official study title

Comparison of Efficacy Between Piracetam and Dimenhydrinate in Patients With Peripheral Vertigo: A Double Blind Randomized Clinical Trial

Important dates

Study start: 2013
Primary completion: 2014
Study completion: 2014
First posted: Jul 1, 2013
Registry last updated: May 5, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed