Comparison of Effects of Oxycodone and Sufentanil on Cardiovascular Stress Induced by Tracheal Intubation in the Patients With Coronary Heart Disease Undergoing Major Noncardiac Surgery

To evaluate the effect of oxycodone and sufentanil in preventing cardiovascular responses to tracheal intubation in the patients with coronary heart disease (CHD).

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Key information

Conditions

Cardiovascular

Age range

60 year–85 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

shengjing hospital of China medical university

Shenyang, Liaoning, 110004, China

About this study

Laryngoscopy and tracheal intubation can provoke an increase of blood pressure (BP) and/or HR [1.2]. This hemodynamic stress may lead to an imbalance between myocardial oxygen consumption and supply and therefore induce myocardial ischemia, which may be endurable in the patients with normal cardiovascular condition but is potential harmful to the patients with coronary heart disease. Thus it is critical to attenuate the cardiovascular stress induced by laryngoscopy and endotracheal intubation in the high risk patients.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

The coronary angiography from each patient showed that lesions exist in at least one main coronary artery

Exclusion criteria

a history of reactive airway disease, gastroesophageal reflux, morbid obesity, a known or predicted difficult airway

Treatment and study plan

Oxycodone 10mg

Drug

induction with 0.3mg/kg of oxycodone in general anesthesia

Sufentanil

Drug

induction with 0.3 µg/kg of Sufentanil in general anesthesia

Primary outcomes

blood pressure(SBP)、diastolic blood pressure(DBP)、mean arterial pressure(MAP)

Time frame: one second before anesthesia induction, the moment when tracheal catheter passes through glottis and at 1, 3, 5 min after tracheal intubation

Under local anesthesia invasive artery line was put to the patients to monitor systolic blood pressure(SBP)、diastolic blood pressure(DBP)、mean arterial pressure(MAP)

Sponsors and collaborators

Lead sponsor

Shengjing Hospital

Other

Registry information

Important dates

Study start: 2019
Primary completion: 2019
Study completion: 2019
First posted: Oct 9, 2019
Registry last updated: Oct 9, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed