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NCT Number: NCT07160101

Comparison of Effects of Eggshell Derived Nano Hydroxyapatite and Hydroxyapatite in Management of Periodontal Intrabony Defects

The aim of the study is to evaluate osseous regenerative efficacy of eggshell derived nanohydroxyapatite in comparison with hydroxyapatite The test group includes patients with intrabony defects where flap surgery will be performed & Eggshell derived nano hydroxyapatite (ESnHA) is placed.

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Key information

Conditions

Periodontal Intrabony Defects Bone Regeneration

Age range

18 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Svs Institute of Dental Sciences

Mahbūbnagar, Telangana, 509001, India

About this study

Experimental : Main treatment group Eggshell derived nano hydroxyapatite is placed into defect site Comparator : In patients allocated to control group, only Hydroxyapatite is placed.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Presence of Two-walled or three-walled intrabony defects & Probing pocket depths (PPD) of >5mm after initial therapy Systemically healthy male and female patients of age >18 years

Exclusion criteria

Medically compromised patients Pregnant women, Heavy smokers, and Patients who underwent radiotherapy or chemotherapy

Treatment and study plan

Eggshell derived nano hydroxyapatite

Other

Eggshell derived nano hydroxyapatite has high solubility and allows faster integration & replaces with osseous tissue

Hydroxyapatite

Other

Hydroxyapatite has similar chemical composition with crystalline structure of native bone

Primary outcomes

  1. RVG

    Time frame: 3months & 6months

    Radiovisiography will be used to assess bone regeneration achieved post operatively

  2. Probing Depth

    Time frame: 3 months & 6months

  3. Clinical Attachment Level

    Time frame: 3 months & 6 months

Secondary outcomes

  1. Full mouth Plaque index

    Time frame: 3 months & 6 months

    Full mouth plaque index was measured using Turesky modification of the Quigley-Hein Index at baseline, 3 months and 6 months

  2. Full mouth Gingival index

    Time frame: 3 months & 6 months

    Full mouth gingival index was measured using Loe & Silness Index at baseline, 3 months and 6 months

Sponsors and collaborators

Lead sponsor

Dr R Viswa Chandra

Other

Registry information

Official study title

"Comparative Efficacy Of Eggshell Derived Nano Hydroxyapatite Over Hydroxyapatite In The Treatment Of Periodontal Intrabony Defects: A Clinico-Radiographic Study"

Important dates

Study start
2023
Primary completion
2024
Study completion
2025
First posted
Sep 8, 2025
Registry last updated
Sep 15, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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