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Completed

NCT Number: NCT03587779

Comparison of Effect of Equi-MAC Anesthetics on PSI

The aim of this study is to compare the patient state index values produced by equi-MAC of sevoflurane and desflurane in patients undergoing single-agent volatile anesthesia.

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Key information

Conditions

Anesthesia

Age range

19 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Kangbuk Samsung Hospital

Seoul, 03181, South Korea

About this study

There have been several studies comparing electroencephalogram-derived indices produced by sevoflurane and desflurane. However, to the best of our knowledge, there has been no study which compared the two inhaled anesthetics using patient state index. Therefore, the aim of this study is to compare the patient state index values produced by sevoflurane and desflurane at equi-MAC in patients undergoing single-agent inhalation anesthesia.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients aged between 19 and 65 yr
  • patients with American Society of Anesthesiologists physical status classification I or II
  • patients scheduled for elective surgery under volatile anesthesia
  • patients obtaining written informed consent

Exclusion criteria

  • patients with a history of any psychiatric or neurological disease
  • patients receiving any medication affecting the autonomic or central nervous system
  • patients with a history of alcohol or drug abuse
  • pregnant or lactating women

Treatment and study plan

Sevoflurane

Drug

Throughout the study period, anesthesia is maintained with sevoflurane of age-corrected equivalent minimum alveolar concentration.

Other names: Sevorane

Desflurane

Drug

Throughout the study period, anesthesia is maintained with desflurane of age-corrected equivalent minimum alveolar concentration.

Other names: Suprane

Primary outcomes

  1. patient state index

    Time frame: After a 30-min waiting period from the induction of anesthesia

    patient state index value at a steady-state anesthesia of equi-MAC

Sponsors and collaborators

Lead sponsor

Kangbuk Samsung Hospital

Other

Registry information

Official study title

Comparison of the Effect of Sevoflurane and Desflurane on Patient State Index: A Randomized Controlled Trial

Important dates

Study start
2018
Primary completion
2019
Study completion
2019
First posted
Jul 16, 2018
Registry last updated
Sep 3, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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