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Completed

NCT Number: NCT07229885

Comparison of Early Versus Late Trophic Feeding

Local data on the neonatal outcomes in early versus late trophic feeding in preterm very low birth weight neonates in terms of mean hospital stay is scarce. Therefore, the current study was planned with the objective of comparing the neonatal outcomes in early versus late trophic feeding in preterm very low birth weight neonates in terms of mean hospital stay.

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Key information

Conditions

Very Low Birth Weight Infant

Age range

1 day–30 day

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Nishtar Hospital

Multan, Punjab Province, 66000, Pakistan

About this study

Since preterm, very low birth weight births are common in society, an effective treatment modality is needed at the moment. Evaluating the length of hospital stay and occurrence of necrotizing enterocolitis in preterm very low birth weight neonates with respect to two approaches of trophic feeding in local settings will provide an insight into a better implementation of preventive strategies, resulting in reducing the hospital stays and the incidence of necrotizing enterocolitis, and hence reducing the burden on the already meager resources.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Any gender
  • Neonates aged 1-30 days
  • Preterm very low birth weight neonates

Exclusion criteria

  • Neonates transferred from other hospital and already started on antibiotics.
  • Neonates with congenital anomalies, hypoxic ischemic encephalopathy, central nervous system (CNS) impairment, neonatal sepsis, urinary tract infection, or one of twins or higher order multiples (on history and medical record).
  • Non-consenting parents.

Treatment and study plan

Early trophic feeding

Dietary Supplement

Infants will receive trophic (enteral) feeding within the first 48 hours after birth.

Late trophic feeding

Dietary Supplement

Infants will receive trophic (enteral) feeding within the first 72 hours after birth.

Primary outcomes

  1. Incidence of necrotizing enterocolitis

    Time frame: Up to 30 days

    Confirmation of the occurrence of necrotizing enterocolitis based on modified Bell's diagnostic criteria

Secondary outcomes

  1. Hospital stay

    Time frame: through study completion, an average of 1 month

    Total days from admission till final outcome (discharge/death due to any case).

Sponsors and collaborators

Lead sponsor

RESnTEC, Institute of Research

Other

Registry information

Official study title

Comparison of Early Versus Late Trophic Feeding in Preterm Very Low Birth Weight Neonates at a Tertiary Care Hospital

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Nov 17, 2025
Registry last updated
Nov 17, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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