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OpenTrials
Enrolling by Invitation

NCT Number: NCT06682741

Comparison of Different Training Programs on Cognitive Function

The goal of the project is to identify the most effective exercise modalities in terms of neuroprotective effects and FP improvement.

Hypothesis: Dancing will increase BDNF, GDNF and CLU levels to a greater extent than traditional forms of AF, resulting in significantly greater improvements in FP in subjects aged ≥ 60 years. The study will involve 60 women aged ≥ 60 years, randomly and equitably assigned to training groups (i.e., resistance training using body weight, dance) and a control group (i.e., a group of physically inactive women).

Methodology:

Participants: 60 women aged ≥ 60 randomly and equally assigned to training groups (Dance and Resistance training) and a control group (i.e., physically inactive women)

Scientists will compare the impact of different forms of physical activity on cognitive functions

Enrolling by Invitation

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Key information

Conditions

Mild Cognitive Impairment (MCI) Behavior Cognition Disorders Cognitive Dysfunction Mental Disorders Motor Activity Neurocognitive Disorders

Age range

50 year and older

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Poznan University of Physical Education

Poznan, Poland, 61-871

About this study

The training interventions will last 6 months. The intensity of physical activity will be determined as a percentage of maximum heart rate (HRmax), assessed based on a fitness test (Chester Step Test), using data from mobile devices monitoring physical activity. Cognitive function (CF) levels, and the concentrations of GDNF, BDNF, and CLU, as well as the Chester Step Test, will be evaluated twice: once at baseline and once after the training programs. Blood samples for measuring neurotrophin and CLU levels will be collected in the morning, after an overnight fast (approximately 12 hours since the last meal). The concentrations of neurotrophins and CLU will be measured using the ELISA method. CF will be assessed using standardized and validated neuropsychological tests.

Expected Outcomes: Greater improvement in CF in the dance group compared to the resistance training and control groups, with higher levels of BDNF, GDNF, and CLU in the dance group.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • women

Exclusion criteria

  • previous diagnoses of cardiovascular diseases

Treatment and study plan

Exercise

Other

supervised exercise training; twice a week for 12 months

Primary outcomes

  1. tle level of cognitive functions

    Time frame: before and after 12 months of interventions

    Cognitive functioning is assessed using the standardized MoCA test, which has a maximum score of 30 points. A score of 26 or higher is considered normal

Secondary outcomes

  1. blood markers

    Time frame: before and after 12 months of intervention

    Neurotrophins, such as BDNF (Brain-Derived Neurotrophic Factor) and GDNF (Glial-Derived Neurotrophic Factor), as well as clusterin are measured from blood using an ELISA test kit

Sponsors and collaborators

Lead sponsor

Poznan University of Physical Education

Other

Registry information

Official study title

Comparison of the Effects of Different Training Programs on the Levels of Cognitive Function

Important dates

Study start
2024
Primary completion
2026
Study completion
2027
First posted
Nov 12, 2024
Registry last updated
Nov 12, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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