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Completed

NCT Number: NCT00322530

Comparison of Dialysis Strategies in Critically Ill Patients With Acute Renal Failure

The goal of the present study is the comparison of different dialysis strategies in critically ill patients with acute renal failure on the intensive care unit. Patients are treated with either continuous dialysis or hemofiltration. Outcome measures are death, restitution of renal function, days on ICU, hemodynamic stability, dialysis efficiency.

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Key information

Conditions

Dialysis Acute Kidney Injury Acute Renal Failure Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Renal Insufficiency Urogenital Diseases Urologic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Division of Nephrology, University of Heidelberg

Heidelberg, Baden-Wurttemberg, 69120, Germany

About this study

The goal of the present study is the comparison of different renal replacement strategies in critically ill patients with acute renal failure on the intensive care unit. In a prospectively randomized clinical study patients are treated with either continuous dialysis (SLED) or continuous hemofiltration (CVVHD). 200 patients should be included in the study (n=100 each). The primary outcome is death at ICU, secondary outcome measures are restitution of renal function, days on ICU, hemodynamic stability, dialysis efficiency.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients 18 years or older
  • Written informed consent
  • No pre-existing dialysis dependency

Exclusion criteria

  • Minors / children
  • No consent
  • Severe electrolyte disturbances which necessitates special dialysis therapy

Treatment and study plan

Renal replacement therapy

Procedure

ICU patients with acute renal failure were prospectively randomized to either CVVHD or SLED

Other names: sustained low efficiency dialysis (SLED), continous veno-venous hemodiafiltration (CVVHD)

Primary outcomes

  1. Death

    Time frame: 90 days

Secondary outcomes

  1. costs

    Time frame: in hospital

  2. Restitution of renal function

    Time frame: 90 days

  3. days on ICU

    Time frame: in hospital

  4. hemodynamic stability

    Time frame: in hospital

  5. dialysis efficiency

    Time frame: in hospital

Sponsors and collaborators

Lead sponsor

Heidelberg University

Other

Registry information

Official study title

Comparison of Dialysis Strategies in Critically Ill Patients With Acute Renal Failure on the Intensive Care Unit

Acronym: rescue

Important dates

Study start
2006
Primary completion
2008
Study completion
2009
First posted
May 8, 2006
Registry last updated
Aug 24, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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